温胆汤加减治疗白血病化疗胃肠反应26例分析

以自身对照法用温胆汤加减治疗白血病化疗胃肠反应26例。结果表明:温胆汤组总有效率96.2%,对照组总有效率76.0%。两组比较,前者疗效明显优于后者(P<0.05)。认为化疗所致胃肠反应是由于火毒之邪损伤脾胃,痰湿内停,郁而化热,阻塞中焦而致。温胆汤作用在于清胆和胃,祛痰降逆,恢复脾胃升降功能。并认为该方不仅可消除化疗引起的恶心、呕吐等症,且能增强抗肿瘤药物的抗癌活性和机体组织的抗毒能力。

TREATMENT OF 26 CASES WITH CHEMOTHERAPY-INDUCED NAUSEA AND VOMITING BY MODIFIED WEEDAN TANG

Modified Wendan decoction in treating leukemia chemotherapy-induced nausea and vomiting was analysed in 26 cases by means of an autocontrol method.The results showed that the total effective rate in wendan decoction group was 96.2%,and that in the control group 76.0%. The former was superior to the later by comparison (P<0.05).It was considered that chemotherapy-induced nausea and vomiting was caused by accumulation of phlegm-heat in the middle-jiao resulting from a long-term retention of phlegm-damp,and dysfunction of the spleen and stomach by fire-toxin factors.The action of wendan decoction was to restore the function of the spleen and the stomach in ascending and descending by clearing away gallbladder-heat and regulating the stomach,eliminating phlegm-heat and lower the adverse flow of qi.The decoction,therefore,ma not only arrebt nausea and vomiting induced by chemotherapy,but also enhance antineoplastic activity of antineoplastic and antitoxin ability of the body organism.