血浆致动脉硬化指数与2型糖尿病患者颈动脉内膜中层厚度的相关性研究

目的　探讨血浆致动脉硬化指数 (AIP)与 2型糖尿病 (T2 DM)患者颈动脉内膜中层厚度 (IMT)之间的关系。方法　选择 179例 T2 DM患者与 87例正常对照者 ,所有 T2 DM患者按其 IMT分成三个亚组 :IMT≤ 0 .6 5mm ,0 .6 5 mm 1.1m m;测量身高、体质量、体重指数、AIP等临床指标 ,并进行统计学处理。结果　 1与正常对照组相比较 ,T2 DM组呈现出高 TG、低 HDL - c及 AIP值明显升高。 2 ANOVA分析结果示在 T2 DM三亚组间 ,不同 IMT水平的年龄、体重指数 (BMI)、腰臀比 (WHR )、糖尿病病程、血红蛋白 A1C(Hb A1C)、甘油三酯 (TG)、总胆固醇 (TC)、HDL - c、低密度脂蛋白 (L DL - c)、TG/HDL - c、AIP差异有显著性 (P<0 .0 5 ) ;单因素直线相关分析示 IMT与 HDL - c呈负相关 ,与其它各指标呈正相关 ,其中以 AIP的相关系数值为最大 (r=0 .5 97,P=0 .0 0 0 )。 3以 IMT与 AIP及其它各因素作多元线性回归分析 ,结果被选进方程的变量有 WHR(P<0 .0 1) ,糖尿病病程 (P<0 .0 5 ) ,L DL - c(P<0 .0 5 ) ,AIP(P<0 .0 1)。结论　 AIP与 T2 DM患者 IMT具有良好的相关性 ,可以作为 T2 DM患者发生动脉粥样硬化危险性的一个判断指标

Atherogenic Index of Plasma is Associated with Carotid Intima-Media Thickness in Patients with Type 2 Diabetes Mellitus

OBJECTIVE: To investigate the relationship of atherogenic index of plasma (AIP), an indirect indicator of LDL particle size, to carotid intima-media thickness (IMT) in patients with type 2 diabetes mellitus (T2DM) among Chinese Han nationality population. METHODS: One hundred and seventy-nine type 2 diabetic patients and 87 healthy subjects from a population of Chinese Han nationality were included. The AIP is the logarithmically transformed ratio of TG/HDL-c, which may serve as a surrogate method for assessing LDL particle size. The carotid IMT, as a surrogate continuous variable for macroangiopathy, was measured by B-mode ultrasonography in type 2 diabetic patients. The patients with T2DM were divided into three subgroups according to the IMT: IMT < or = 0.65 mm, 0.65 mm < IMT < or = 1.1 mm and IMT > 1.1 mm. The Student-t test, one-way analysis of variance, univariate and multivariate analyses were implemented. RESULTS: (1) In T2DM group the values of triglyeeride (TG) and AIP were significantly higher than those in control group respectively, and the HDL-c value of T2DM group was significantly lower than that of control group. (2) There was significant difference in the age, body mass index (BMI), waist-hip ratio (WHR), the duration of DM, triglyceride (TG), total cholesterol (TC), LDL-c, HDL-c, HbAlc, TG/HDL-c and AIP among the three subgroups; the HDL-c value was inversely related to the IMT of T2DM, and all the other risk factors were positively related to the IMT of T2DM. (3) Multivariate analysis by linear regression showed that the value of AIP was an important risk factor in the pathogenesis and progress of IMT in patients with T2DM. CONCLUSION: AIP value, an indirect indicator of LDL particle size, is an important risk factor in pathogenesis and progress of IMT in patients with T2DM.