福赛斯拟杆菌在感染根管内定植及其与临床症状的关系

目的了解福赛斯拟杆菌在慢性根尖周炎患牙根管内定植情况，探讨该菌与慢性根尖周炎临床症状间的关系。方法收集38例慢性根尖周炎患牙根管标本，采用16SrDNA PCR方法检测福赛斯拟杆菌在根管内分布情况，单因素相关分析福赛斯拟杆菌在根管内定植与慢性根尖周炎疼痛、叩痛、瘘道和肿胀间关系。结果福赛斯拟杆菌在38例慢性根尖周炎根管内检出10例，检出率为26．3％，与慢性根尖周炎的急性发作临床症状疼痛、叩痛、肿胀呈正相关关系(OR分别为∞、9．0、12．0)，有统计学意义(P＜0．05)，与瘘道不存在相关关系(OR=1．33)。结论福赛斯拟杆菌能定植于根管内，是慢性根尖周炎的可疑致病菌。

Association Between Bacteroides forsythus in the Infected Root Canals and Clinical Symptoms of Chronic Apical Periodontitis

OBJECTIVE: To investigate the distribution of Bacteroides forsythus in root canals with chronic apical periodontitis and to determine its associations with clinical symptoms. METHODS: Thirty-eight tooth root canals from 31 subjects were studied with a 16S rDNA-directed polymerase chain reaction (PCR). These teeth were classified into symptomatic and asymptomatic groups according to the clinical symptoms and signs, including spontaneous pain, percussion pain, sinus tract and swelling, respectively. RESULTS: Ten of the 38 root canal samples were positive for B. forsythus. The prevalence of B. forsythus was 26.3% for 38 root canals, 45.5% for spontaneous pain group, 39.1% for percussion pain group, 29.4% for sinus tract group, 42.9% for swelling group, respectively. Significant positive associations were observed between B. forsythus in infected root canals and the spontaneous pain, percussion pain, and swelling of apical periodontitis, respectively (OR=infinity, 9, 12; P<0.05). There was no significant association between B. forsythus and sinus tract of apical periodontitis (OR=1.33). CONCLUSION: B. forsythus colonized in the infected root canals. It is the putative pathogen of apical periodontitis.