四川蒙顶绿茶对大鼠食管癌预防阻断效果的实验研究

实验选用Ｗｉｓｔａｒ大鼠，分为三组（单亚组、实验组、空白组，每组各５０只），实验组大鼠开始即饮用２％的绿茶液（普通级别），持续至实验结束。２周后单亚组及实验组同时开始肌注甲基戊基亚硝胺，５ｍｇ／ｋｇ，每周１次，持续２０周。分４次处死动物（每６周各组处死１０只，第２４周处死剩余动物）。结果各阶段处死及食管癌总的发生率有明显差异，显示绿茶对大鼠食管癌的发生有预防阻断作用。

A Preliminary Study of the Preventive and Blocking Effect of Green Tea Grown in Mengding Mountain Area on the Esophageal Cancer in Rats

Three groups (positive control or nitrosamine alone group, test group and control group) were included in this experiment. After the begining of the experiment, the rats of test group were given 2% green tea (common grade) solution by free drinking daily for 24 weeks. After 2 weeks of the begining of the experiment, the rats of the nitrosamine alone group and test group were injected with MANA, 5 mg/kg weekly for 20 weeks. The animals were sacrificed at 4 intervals. The incidence rates of esophageal cancer in the rats of the two groups sacrified at every interval were significantly different. The result suggested that green tea should have a preventive and blocking effect on the occurrence of esophageal cancer in rats.