| 食管鳞癌中VEGF-C、VEGF-D的表达与临床病理特征的相关性研究 |
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| 引用本文： | 蒋明,勾红峰,杨雨,曹丹,侯梅.食管鳞癌中VEGF-C、VEGF-D的表达与临床病理特征的相关性研究[J].四川大学学报(医学版),2009,40(2). |
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| 作者姓名： | 蒋明 勾红峰 杨雨 曹丹 侯梅 |
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| 作者单位： | 四川大学华西医院,肿瘤中心,成都,610041 |
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| 摘 要： | 目的 检测血管内皮生长因子-C、D(VEGF-C和VEGF-D)在食管鳞癌中的表达与各临床病理特征之间的关系,探索食管鳞癌淋巴结转移的机制.方法 免疫组化法检测VEGF-C、D在62例食管鳞癌根治术后标本及20例癌旁正常组织中的表达,计数微淋巴管密度(MLD).分析VEGF-C、D表达及MLD与临床病理特征之间的关系.结果 肿瘤组织中VEGF-C和VEGF-D的高表达率分别是74%(46/62)和82%(51/62);肿瘤边缘MLD(5.387±4.986)明显高于癌旁正常组织(1.900±2.245)(P<0.05).VEGF-C、D高表达组与低表达组相比,淋巴结转移更常见、临床分期也较晚,MLD增加与VEGF-C、D高表达、有淋巴结转移及临床分期较晚有关.VEGF-C和VEGF-D的表达有正相关关系(r=0.691,P<0.001).结论 VEGF-C和VEGF-D在食管鳞癌中可能通过增加肿瘤周边区域的淋巴管新生促进肿瘤的淋巴道转移.
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| 关 键 词： | 食管鳞癌 淋巴管生成 |
Relationship Between Clinicopathologic Characteristics and Expression of VEGF-C and VEGF-D in Esophageal Squamous Cancer |
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| JIANG Ming,GOU Hong-feng,YANG Yu,CAO Dan,HOU Mei.Relationship Between Clinicopathologic Characteristics and Expression of VEGF-C and VEGF-D in Esophageal Squamous Cancer[J].Journal of West China University of Medical Sciences,2009,40(2). |
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| Authors: | JIANG Ming GOU Hong-feng YANG Yu CAO Dan HOU Mei |
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| Institution: | JIANG Ming,GOU Hong-feng,YANG Yu,CAO Dan,HOU Mei.Center of Oncology,West China Hospital,Sichuan University,Chengdu 610041,China |
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| Abstract: | Objective To investigate the relationship between clinicopathologic characteristics and expressions of vascular endothelial growth factor-C,D(VEGF-C and VEGF-D) in esophageal squamous cancer.Methods The tumor tissues were collected from 62 cases of esophageal squamous carcinoma,and 20 paracancerous tissues were used as control.The expressions of VEGF-C and VEGF-D were detected by immunohistochemical method,and the count of micro lymphatic density(MLD) was measured.We analyzed their relationships with tumor ... |
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| Keywords: | VEGF-C VEGF-D |
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