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中药影响变形链球菌对唾液获得性膜粘附的研究
引用本文:黄正蔚,周学东,李继遥,刘天佳,李红,朱昞.中药影响变形链球菌对唾液获得性膜粘附的研究[J].四川大学学报(医学版),2003,34(1):135-137.
作者姓名:黄正蔚  周学东  李继遥  刘天佳  李红  朱昞
作者单位:四川大学华西口腔医学院,成都,610041
基金项目:国家自然科学基金 (批准号 3 0 171175 ),四川省教育厅国际合作项目基金 (编号 413 0 2 0 )资助
摘    要:目的:研究不同传统中药提取物对变形链球菌在唾液获得性膜粘附的影响,进一步探讨中药防龋的可能机制。方法:采用唾液包被羟磷灰石(S-HA)形成实验性获得性膜的体外模式,以变形链球菌作为试验菌株,用不同的药物提取物分别处理S-HA和菌细胞,观察细菌对S-HA的粘附情况。结果:两组试验中大部分试验药物均能抑制菌细胞对S-HA的粘附,且随药物浓度的升高而逐渐增强。这些药物中,以五倍子的抑制作用表现更为显著,其在1、2、4mg/ml时的抑制率可达100%。结论:五倍子等传统中药能有效抑制变形链球菌对唾液获得性膜的早期粘附。

关 键 词:传统中药  五倍子  变形链球菌  唾液获得性膜  粘附
修稿时间:2002年4月19日

The Effects of Traditional Chinese Medicines on the Adherence of Streptococcus mutans to Salivary Acquired Pellicle in vitro
Huang Zhengwei,Zhou Xuedong,Li Jiyao,Liu Tianjia,Li Hong,Zhu Bing. West China School of Stomatology,Sichuan University,Chengdu ,China.The Effects of Traditional Chinese Medicines on the Adherence of Streptococcus mutans to Salivary Acquired Pellicle in vitro[J].Journal of West China University of Medical Sciences,2003,34(1):135-137.
Authors:Huang Zhengwei  Zhou Xuedong  Li Jiyao  Liu Tianjia  Li Hong  Zhu Bing West China School of Stomatology  Sichuan University  Chengdu  China
Institution:West China School of Stomatology, Sichuan University, Chengdu 610041, China.
Abstract:Objectives To investigate the effects of traditional Chinese medicines on the preliminary adherence of Streptococcus mutans to salivary acquired pellicles. Methods The hydroxyapatites beads were coated by saliva to form S HA, an in vitro model of experimental pellicle. Streptococcus mutans was chosen as the experiment strain, and radiolabeled with 3H thymidine. Two parts of adherence inhibit study were carried on with medicines pretreated S HA and medicines pretreated bacteria. The numbers of 3H thymidine labeled bacteria attached to S HA were counted by scintillation counting to indicate the amount of adherence. Results It was found that most of the traditional Chinese medicines tested could inhibit the adherence to S HA to different extent, especially the Galla Chinensis, which has significant inhibitory action. Conclusion Galla Chinensis may be a prospective medicine to inhibit the cariogenic bacteria's preliminary adherence to salivary acquired pellicles.
Keywords:Traditional Chinese medicine      Galla Chinensis        Streptococcus mutans      Salivary acquired pellicles    Adherence
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