非小细胞肺癌组织中CD44v6和Paxillin的表达及其与预后的关系

目的　研究细胞粘附分子在非小细胞肺癌组织中的表达及其与转移和预后的关系。方法　通过免疫组化的方法检测 79例非小肺癌组织中 CD44 v6和 Paxillin表达并分析其与肿瘤的组织类型、分化程度、淋巴结转移与预后的关系。结果　肺癌组织中 CD44 v6和 Paxillin的阳性率分别为 60 .8%和 3 4.1%。CD44 v6的表达与肺癌淋巴结转移呈正相关 ,与 2年生存率呈负相关 ( P均 <0 .0 5 )。 Paxillin的表达与肺癌淋巴结转移呈正相关 ( P均 <0 .0 5 )。结论　 CD44 v6和 Paxillin与肺癌的淋巴结转移和预后有着密切关系

Relationship of the Expression of CD44v6 and Paxillin to the Prognosis of Non-small Cell Lung Carcinoma

Objective To investigate the expression and significance of CD44v6 and Paxillin in non-small cell lung carcinoma. Methods Immunohistochemical staining was used to detect the expression of CD44v6 and Paxillin in 79 cases of non-small cell lung carcinoma, and the relationships of the expression with histological type, lymph node metastasis and prognosis were detected. Results The expression rates of CD44v6 and Paxillin were 60.8% and 34.1% respectively. The expression of CD44v6 was positively correlated with metastasis and negatively correlated with the 2-year survival rate (P<0.05). The expression of Paxillin was positively correlated with metastasis (P<0.05). Conclusion The expression of CD44v6 and Paxillin is closely correlated with the lymph node metastasis and the prognosis of non-small cell lung carcinoma.