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胸腺五肽三甲基壳聚糖口服纳米粒的研究
引用本文:唐仕炜,袁晓佳,张志荣,宋庆国,何勤.胸腺五肽三甲基壳聚糖口服纳米粒的研究[J].四川大学学报(医学版),2007,38(5):885-888.
作者姓名:唐仕炜  袁晓佳  张志荣  宋庆国  何勤
作者单位:四川大学华西药学院,靶向药物教育部重点实验室,成都,610041
摘    要:目的 制备能口服给药的胸腺五肽三甲基壳聚糖纳米粒,并观察其口服给药的药效作用. 方法首先合成三甲基壳聚糖(TMC),然后采用中心组合设计优化制备工艺,制备胸腺五肽的三甲基壳聚糖口服纳米粒(Tp5-TMC-NP).用流式细胞仪测定Wistar大鼠口服给药后对T细胞CD4 /CD8 的影响. 结果采用优化工艺制备的Tp5-TMC-NP为规则圆球状,粒径范围窄,平均粒径110.6 nm,包封率78.8%.Tp5-TMC-NP经Wistar大鼠灌胃给药,流式细胞仪测定(CD4 /CD8 )/Dosage为5.65,为胸腺五肽(Tp5)直接灌胃(2.18)的2.59倍. 结论口服Tp5-TMC-NP效果明显优于Tp5口服.

关 键 词:胸腺五肽  口服给药系统  纳米粒  N-三甲基壳聚糖  胸腺五肽  三甲基壳聚糖  纳米粒  研究  Mouth  Chitosan  Nanoparticles  效果  灌胃给药  Dosage  包封率  平均粒径  粒径范围  球状  规则  工艺制备  优化制备工艺  结果  影响  流式细胞仪  大鼠
修稿时间:2006-11-032007-03-12

Research on Thymopentin-loaded N-trimethyl Chitosan Nanoparticles Administered through Mouth
TANG Shi-wei,YUAN Xiao-jia,ZHANG Zhi-rong,SONG Qing-guo,HE Qin.Research on Thymopentin-loaded N-trimethyl Chitosan Nanoparticles Administered through Mouth[J].Journal of West China University of Medical Sciences,2007,38(5):885-888.
Authors:TANG Shi-wei  YUAN Xiao-jia  ZHANG Zhi-rong  SONG Qing-guo  HE Qin
Institution:Key Laboratory of Drug Targeting, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China
Abstract:Objective To prepare a peroral thymopentin-loaded N-trimethyl chitosan chloride-nanoparticle(Tp5-TMC-NP),and observe the pharmacodynamic action when the Tp5-TMC-NP is taken by way of the mouth.Methods N-trimethyl chitosan chloride was first synthesized,and then Tp5-TMC-NP was prepared with the formulation technology optimized by the Central Composite Design.The influence of Tp5-TMC-NP on the ratio of CD4 /CD8 of T-lymphocytes were determined by flow cytometer.Results The regular global Tp5-TMC-NP prepared with the optimized formulation craft had the mean diameter of 110.6 nm and got the entrapment efficiency of 78.8%.The ratio of lymphocyte CD4 /CD8 of Wistar rat administered with Tp5-TMC-NP perfusing stomach had 2.59 times higher than that with Tp5.Conclusion Taking orally the Tp5-TMC-NP has much higher efficiency than Tp5.
Keywords:Thymopentin(Tp5) Oral drug delivery system Nanoparticle N-trimethyl chitosan(TMC)
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