5种天然药物对变形链球菌在唾液获得性膜粘附的影响

目的 研究大黄、槟榔、白芷、川芎和儿茶5种天然药物对变形链球菌在唾液获得性膜粘附的影响。方法 采用唾液包被的羟磷灰石(S-HA)形成实验性膜的体外模式，用天然药物处理S-HA和变形链球菌，观察变形链球菌在S-HA粘附的情况。结果 大黄、槟榔和川芎可明显抑制变形链球菌对S-HA的粘附，且槟榔的抑制作用最为显著，而白芷对变形链球菌的粘附无明显影响，儿茶仅在处理变形链球菌时对其粘附有抑制作用。结论 大黄、槟榔、川芎和儿茶对变形链球菌在唾液获得性膜的粘附有一定的抑制作用，而白芷对变形链球菌的粘附无明显影响。

The Effects of Natural Medicine on Adherence of Streptococcus mutans to Salivary Acquired Pellicle

Objective To investigate the effects of 5 kinds of natural medicine such as Radix et Rhizoma Rhei on the adherence of Streptococcus mutans to salivary acquired pellicle, and to screen effective natural medicines for the prevention of caries. Methods The in vitro model of experimental pellicle was saliva-coated hydroxyapatites(S-HA). Streptococcus mutans and S-HA were treated with natural medicines respectively, and then the adherence of bacteria to S-HA was tested. Results Radix et Rhizoma Rhei, Semen Arecae and Rhizoma Liguistici Chuanxiong could decrease the attachment of Streptococcus mutans to S-HA, and Semen Arecae was the most effective one. Radix Angelicae Dahuricae had no remarkable effect, and Catechu inhibited the adherence only after the bacteria being under treatment. Conclusion Radix et Rhizoma Rhei, Semen Arecae, Rhizoma Liquistici Chuanxiong and Catechu could effectively inhibit the adherence of Streptococcus mutans to salivary acquired pellicle, but the effect of Radix Angelicae Dahuricae on the adherence is un-noticeable.