| 用室模型与非室模型研究铬剂在家兔体内的药代动力学 |
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| 引用本文： | 陈淑清,黑永疆,周伦惠,陈淑杰,严保珍,杨家灿,郭积佑.用室模型与非室模型研究铬剂在家兔体内的药代动力学[J].四川大学学报(医学版),1988(1). |
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| 作者姓名： | 陈淑清 黑永疆 周伦惠 陈淑杰 严保珍 杨家灿 郭积佑 |
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| 作者单位： | 华西医科大学药学院药理学教研室
(陈淑清，黑永疆，周伦惠，陈淑杰)，华西医科大学药学院无机化学教研室
(严保珍，杨家灿)，华西医科大学药学院无机化学教研室(郭积佑) |
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| 摘 要： | 作者给家兔静注和口服三价有机铬剂 1 mg/kg,于给药前及给药后不同时间取血,用原子吸收光谱法测得血中铬浓度,以室模型和非室模型分析法计算各药代动力学参数。结果表明:静注铬剂后其血药浓度的变化符合二室模型,T_(1/2)α=1.28h,T_(1/2)β=52.2h,V_d=1.26 (L/kg),Cl=0.022(L/h·kg)。用非室模型法计算所得参数值与上述各数据相近。口服铬剂后其血药液度变化不符合室模型理论,故用非室模型法计算各参数。口服铬剂吸收不良,生物利用度F=4.39％。
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| 关 键 词： | 铬剂 室模型 非室模型 药代动力学 |
PHARMACOKINETIC STUDY OF CHROMIUM PREPARATION IN RABBITS BY COMPARTMENT AND NON-COMPARTMENT ANALYSIS |
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| Chen Shuqing,Hei Yongjiang,Zhou Lunhui,Chen Shujie.PHARMACOKINETIC STUDY OF CHROMIUM PREPARATION IN RABBITS BY COMPARTMENT AND NON-COMPARTMENT ANALYSIS[J].Journal of West China University of Medical Sciences,1988(1). |
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| Authors: | Chen Shuqing Hei Yongjiang Zhou Lunhui Chen Shujie |
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| Institution: | Chen Shuqing,Hei Yongjiang,Zhou Lunhui,Chen Shujie Department of Pharmacology,School of Pharmacy Yan Baozhen,Yang Jiacan,Guo Jiyou Department of Inorganic Chemistry,School of Pharmacy |
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| Abstract: | |
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| Keywords: | Chromium preparation Pharmacokinetics compartment model Non-compartment model |
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