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正常成人海马结构、杏仁核及前颞叶的MRI体积测量
引用本文:邹翎,肖家和,周翔平,孙昌进,熊燕.正常成人海马结构、杏仁核及前颞叶的MRI体积测量[J].四川大学学报(医学版),2003,34(4):719-722.
作者姓名:邹翎  肖家和  周翔平  孙昌进  熊燕
作者单位:1. 四川大学华西医院,放射科,成都,610041
2. 南京市第一人民医院
摘    要:目的 确定正常成人海马结构、杏仁核及前颞叶体积的正常值范围。方法 对 10 2例 2 0岁及以上无中枢神经系统疾病的正常受试者分组后行头颅斜冠状位 MRI扫描 ,在 T1 WI上测定各结构体积。结果 标准化后前颞叶体积均值 :右侧 :2 0岁~组 5 9.0 7± 2 .0 2 cm3;4 0岁~组 5 5 .5 5± 2 .2 3cm3;≥ 6 0岁 ,5 2 .88± 2 .0 7cm3。左侧 :2 0岁~组 5 7.2 5± 2 .15 cm3;4 0岁~组 5 3.2 3± 1.72 cm3;≥ 6 0岁组 5 1.6 3± 2 .0 2 cm3。杏仁核体积均值为 :右侧 :2 0岁~组 1.5 4± 0 .0 9cm3;4 0岁~组 1.38± 0 .0 8cm3;≥ 6 0岁组 1.2 9± 0 .0 9cm3。左侧 :2 0岁~组 1.37± 0 .0 9cm3;4 0岁~组 1.2 9± 0 .0 8cm3;≥ 6 0岁组 1.2 3± 0 .0 9cm3。海马结构 2 0~ <6 0岁年龄段正常值右侧为 :2 .5 2~ 3.11cm3,左侧 2 .4 0~ 2 .98cm3;≥ 6 0岁组右侧及左侧正常值范围分别为 :2 .33~ 2 .6 5 cm3,1.98~ 2 .6 4 cm3。海马结构体积在 6 0岁以后减小较明显。上述结构体积在男女及利手分组中无显著性差异 ,均与年龄呈负相关。结论  MRI能有效地评价海马结构、杏仁核和前颞叶的体积 ,为临床某些精神和神经系统疾病的诊断和治疗提供有价值的参考依据

关 键 词:海马结构  杏仁核  前颞叶  体积测量  磁共振
修稿时间:2002年9月16日

Hippocampal Formations, Amygdala and Anterior Temporal Lobes:Normative Volumetric Measurements from MR Iamging in Normal Adults of China
Zou Ling ,Xiao Jiahe,Zhou Xiangping,Sun Changjin,Xiong Yan.Hippocampal Formations, Amygdala and Anterior Temporal Lobes:Normative Volumetric Measurements from MR Iamging in Normal Adults of China[J].Journal of West China University of Medical Sciences,2003,34(4):719-722.
Authors:Zou Ling  Xiao Jiahe  Zhou Xiangping  Sun Changjin  Xiong Yan
Institution:Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Abstract:OBJECTIVE: To define the normal range of volumetric values of hippocampal formations (HPF), amygdala (AM) and anterior temporal lobes (ATL). METHODS: One hundred and two Chinese normal adults underwent MRI scan on oblique coronal section. Volumes of the anterior temporal lobes, hippocampal formations and amygdala were obtained on T1WI. The mean values and the range of 95% normal values were obtained by statistical data processing and analysis. RESULTS: The mean values of standardized volumes of anterior temporal lobes in the subjects aged 20 yr.-, 40 yr.- and > or = 60 yr. were: 59.07 +/- 2.02 cm3, 55.55 +/- 2.23 cm3, 52.88 +/- 2.07 cm3 (Right); 57.25 +/- 2.15 cm3, 53.23 +/- 1.72 cm3, 51.63 +/- 2.18 cm3 (Left); and of amygdala in those aged 20 yr.-, 40 yr.- and > or = 60 yr. were: 1.54 +/- 0.09 cm3, 1.38 +/- 0.08 cm3, 1.29 +/- 0.09 cm3 (R); 1.37 +/- 0.09 cm3, 1.29 +/- 0.08 cm3, 1.23 +/- 0.09 cm3(L). The 95% normal values of HPF in the subjects aged 20 yr.- ranged from 2.52 to 3.11 cm3(R), and from 2.40 to 2.98 cm3(L); in those aged > or = 60 yr. ranged from 2.33 to 2.65 cm3 (R) and from 1.98 to 2.64 cm3(L). There was no significant difference in the volumes of hippocampal formations between two groups under 60 yr.. And a decrease of the volumes of hippocampal formations could been seen in the > or = 60 yr. group. No significant difference in the volumes of hippocampal formations, amygdala and anterior temporal lobes was seen in the sex groups and handedness groups. CONCLUSION: The data on standardized volumes of HPF, AM, ATL in this study can serve as a foundation on which to provide normal index and useful guidelines for reference in early diagnosis and treatment of Alzheimer's disease and temporal lobe epilepsy.
Keywords:Hippocampal formation    Amygdal    Anterior temporal lobe    Volumetric measurement    MRI
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