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乳腺癌中C-erbB2癌基因与雌、孕激素受体和PS2的关系及其预后意义
引用本文:杨金巧,陈琳,幸天勇.乳腺癌中C-erbB2癌基因与雌、孕激素受体和PS2的关系及其预后意义[J].四川大学学报(医学版),2004,35(3):334-336,357.
作者姓名:杨金巧  陈琳  幸天勇
作者单位:1. 四川大学华西医院,普外科,成都,610041
2. 川北医学院,普外科
摘    要:目的 探讨 C- erb B2癌基因在乳腺癌中的表达及其与雌激素受体 (ER)、孕激素受体 (PR)及 PS2的关系和预后意义。方法 采用链亲和素法检测 2 4 5例乳腺癌中 C- erb B2的表达。结果 约 6 0 %的乳腺癌有 C- erb B2癌基因表达 ,C- erb B2表达阳性率在 ER、PR及 PS2阳性组分别为 4 5 .19% ,4 8.0 8% ,2 3.2 6 % ,在 ER、PR及 PS2阴性组分别为 71.5 5 % ,70 .4 3% ,5 0 .75 % ,C- erb B2癌基因表达与 ER、PR及 PS2均分别呈负相关 (P<0 .0 5 ) ,其表达与患者年龄、肿瘤大小无关 (P>0 .0 5 ) ,与乳腺癌临床分期晚、组织学分级高、腋淋巴结转移有关 (P<0 .0 5 )。结论检测 C- erb B2癌基因在乳腺癌中的表达有助于乳腺癌预后的判断及治疗方案的制定。

关 键 词:乳腺癌  C-erbB2癌基因  雌激素受体  孕激素受体  雌激素调节系统
修稿时间:2003年6月17日

Relationship of Oncogene C-erbB2 Expression to ER,PR and PS2 in Breast Cancer and Its Prognostic Significance
YANG Jin-qiao,CHEN Lin,XING Tian-yong.Relationship of Oncogene C-erbB2 Expression to ER,PR and PS2 in Breast Cancer and Its Prognostic Significance[J].Journal of West China University of Medical Sciences,2004,35(3):334-336,357.
Authors:YANG Jin-qiao  CHEN Lin  XING Tian-yong
Institution:Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Abstract:Objective To explore the expression of oncogene C-erbB2 in breast cancer, its relationship to estrogen receptor(ER), progesterone receptor(PR) and PS2 and the prognostic significance. Methods The expression of oncogene C-erbB2 in 245 cases with breast cancer was detected with immunohistochemical technique(LsAB). Results Expression of oncogene C-erbB2 was found in 60% cases of breast cancer. Tumors positive for C-erbB2 were 45.19% and 71.55% in ER positive group and ER negative group respectively, while tumors positive for C-erbB2 were 48.08% and 70.43% in PR positive group and PR negative group respectively. The expression of the C-erbB2 was 23.26% in group of PS2 positive and 50.75% in group of PS2 negative(P<0.05). No significant association of C-erbB2 expression with age and tumor size was noted(P>0.05), but its expression in breast cancer was correlated with advanced clinical stage, high histological grade, axillary lymph node involvement(P<0.05). Conclusion C-erbB2 would be helpful to the evaluation of prognosis and treatment in breast cancer.
Keywords:Breast cancer    Oncogene C-erbB2    Estrogen receptor    Progesterone receptor    Estrogen regulated system
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