一起由新甲1型流感病毒变种引起的流感爆发

本文报告1986年4月成都某大学的一起流感爆发,学生中罹患率高达28％,流行高峰在4天以内。从32份急性期流感病人咽漱液标本中共分离出三株病毒。经病毒学鉴定和患者双份血清的血清学试验证实,此新分离的三株病毒均属新甲1型流感病毒的变种,其抗原性与我国北方正在流行的A1/青防85-42相似。提示新甲1型流感病毒的变种在我国已由北向南传播。

AN OUTBREAK OF INFLUENZA ARISEN FROM THE VARIANT STRAINS OF NEW INFLUENZA A[H_1N_1]

In the present paper, the results ofinvestigation of influenza outbreak arisenfrom variant strains of new influenzaAH_1N_1] in a university at Chengdu inApril 1986 are presented. The number ofceaes was 827(attack rate was 15 percent),in which attack rate in students was 28percent. Thirty two gargle specimens fromacuteperiod influenza cases were collected.Three strains viruses were isolated fromthese specimens. Surface antigens of these tnree strains viruses were idenitified byhemagglutination inhibition test(HI) usingstandard immune serum of influenzaof different subtypes. The results of HIshowed that antigenicity of three isolateswere similar to A/Qingdao /85-42 H_1N_1]which was variants of new influenza AH_1 N_1]. In addition, twenty one pair serumspecimens collected from acute period andconvalescence cases were examined by HIusing these three new strain viruses isola-ted as well as A/Qingdao/85-42 H_1N_1].The results showed that titre of HI anti-bodies rise twice to eightfold in 61.8 per-cent convalescence serum specimens. Our results suggest that the variantsof new influenza A H_1N_1] might betrasmitted from the north to the south inour country.