动脉粥样硬化性脑梗死急性期患者血清Apelin-13水平及其与病情的关系

目的:探讨急性期动脉粥样硬化性脑梗死患者血清Apelin-13水平及其与病情的关系.方法:选取我院神经内科2013年1月~2014年12月收治的急性脑梗死患者150例(脑梗塞组).选取体检健康者例作为对照组.患者采用美国国立卫生研究院脑卒中量表(NIHSS)对脑梗死组进行神经功能缺损评分,应用ELASA的方法检测患者血清Apelin-13水平,分析脑梗死组血清Apelin-13水平与神经功能缺损评分、英国牛津郡社区脑卒中项目(OCSP)分型、梗死部位和梗死面积之间的关系.结果:脑梗死组患者血清Apelin-13水平明显高于对照组,不同的OCSP分型、梗死面积、梗死部位的血清Apelin-13水平之间差异有统计学意义,其中完全性前循环梗死>后循环梗死>部分前循环梗死>腔隙性脑梗死;大面积脑梗死>小面积脑梗死>腔隙性梗死.而不同梗死部位的患者血清Apelin-13水平差异无统计学意义,急性期脑梗死患者Apelin-13水平与NIHSS评分呈正相关.结论:急性期脑梗死患者血清Apelin-13水平升高,且随着脑梗死面积增大而升高,但与梗死的部位无相关性,因此Apelin-13水平检测对患者的病情评估有一定的意义.

The Serum Level of Apelin-13 in Patients with Acute Cerebral Infarction and Its Relationship with Severity of Illness

Objective To investigate the serum level of Apelin-13 in patients with acute cerebral infarction and its rela-tionship with severity of illness. Methods patients with acute cerebral infarction (time of onset <72h) who admitted to neurol-ogy Department from January 2013 to December 2014, was included as the cerebral infarction group, and healthy people were selected as control group, the gender and age of control group were similar to those of cerebral infarction group. The clinical date of all patients was collected, neurologic impairment scores in the cerebral infarction group were evaluated using NIHSS. The serum level of Apelin-13 of all cases. The relationships between the serum level of Apelin-13 and OCSP subtype, infarct size, infarct location and NIHSS score were investigated. Results The serum level of Apelin-13 in cerebral infarction group was significantly higher than that in control group. The serum level of Apelin-13 in cerebral infarction group changed with OCSP subtype and infarct size, the differences was statistically significant; The serum level of Apelin-13 in patients with total anterior circulation infarct, posterior circulation infarct, partial anterior circulation infarct, lacunar infarct decreased progressively, it also decreased in patients with big size cerebral infarction, small size cerebral infarction and lacunar infarct. There was no significant difference in the serum level of Apelin-13 among patients with different infarct locations. The serum level of Apelin-13 was positively correlated with NIHSS score among patients with actue cerebral infarction. Conclusion The serum level of Apelin-13 in patients with acute cerebral infarction was significantly higher than that in healthy people, and increased with the increased the infarct size. However, there was no relationship between Apelin-13 levels and infarct locations. The serum Apelin-13 might be a new biological marker to predict the severity and prognosis of ischemic stroke.