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HPV E6/E7mRNA和HC2-HPV-DNA检测对宫颈病变筛查的意义
引用本文:贾政军,周玉春,胡蓉,彭向京,黄定梅,王华,王丹,何思.HPV E6/E7mRNA和HC2-HPV-DNA检测对宫颈病变筛查的意义[J].湖南师范大学学报(医学版),2012,9(4):51-54.
作者姓名:贾政军  周玉春  胡蓉  彭向京  黄定梅  王华  王丹  何思
作者单位:湖南省妇幼保健院遗传室,湖南长沙,410008
摘    要:目的:研究TCT联合HC2-HPV-DNA在宫颈病变诊断中的意义。方法:收集湖南省妇幼保健院怀疑宫颈病变的女性187例,行阴道镜检测,用宫颈拭子获取脱落细胞进行HC2-HPV-DNA和TCT检测,同时进行病理学活检。以病理诊断结果为金标准,计算TCT、HC2-HPV-DNA及两者联合检测筛查宫颈病变的敏感度、特异度、假阳性率、假阴性率和诊断符合率,评价其诊断价值。结果:HC2-HPV-DNA对宫颈病变的筛查敏感性高于HPV E6/E7mRNA TCT检测(分别为83.61%及75.41%),但其特异度明显低于后者(分别为52.38%及74.60%),两种检测均存在较高的假阳性率(25.40%及47.62%),两者联合检测可提高诊断的特异度(81.95%)及诊断符合率(78.07%)。结论:TCT和HC2-HPA-DNA联合检测可提高特异度及诊断符合率,在妇女宫宫颈病变筛查中具有较高的应用价值。

关 键 词:HC2-HPV-DNA  TCT  宫颈癌  宫颈癌前病变  人乳头瘤病毒

Application of TCT and HC2-HPV-DNA in cervical lesions screening of wemen
Jia Zhengjun,Zhou Yuchun,Hu Rong,Peng Xiangjing,Huang Dingmei,Wang Hua,Wang Dan,He Si.Application of TCT and HC2-HPV-DNA in cervical lesions screening of wemen[J].Journal of Hunan Normal University(Medical Science),2012,9(4):51-54.
Authors:Jia Zhengjun  Zhou Yuchun  Hu Rong  Peng Xiangjing  Huang Dingmei  Wang Hua  Wang Dan  He Si
Institution:(Department of Genetics,Maternal and Child Health Hospital of Hunan Province,Changsha 410008,China)
Abstract:Objective To research the application of the TCT and HC2-HPV-DNA in cervical lesions screening project.Methods The test results of TCT and HC2-HPV-DNA of 187 cases were used and compared. Based on the pathologydiagnosis,specificity and sensitivity of these two screening methods were calculated. Results HC2 had hisher sensitivity(83.61%) and lower specificity(52.38%) than TCT(75.41% and 74.60%) respectively.Both of them had high false positive rates,HC2 25.7% and TCT 45.7%.Co-test of these two methods increased the specificity to 81.95% and the consistency rate to 72.13%.There were no significant differences amongfalse negative rates of TCT,HC2 and CO-test.Conclusion In the cervical lesions screening of women, TCT and HC2 co-test decreased the false positive rate and increased thespecificity and diagnosis coincidence rate.The co-test method was valuable in the cervical lesions screening of women.
Keywords:thinprep cytology test  human papillomavirus  cervical lesions  screening
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