氧驱雾化吸入盐酸氨溴索治疗COPD急性加重期患者的临床疗效观察

目的：研究氧驱雾化吸入盐酸氨溴索治疗COPD急性加重期患者的临床疗效观察。方法：从2012年1月到2014年1月，我院共收治156名COPD急性加重期患者，随机选取其中的162例患者进行临床试验，用随机数据表法将其分为观察组和对照组。每组81例，所有患者均进行COPD急性加重期的常规治疗，观察组在此基础上进行氧驱雾化吸入盐酸氨溴索治疗。对比分析两组患者的治疗疗效、血气分析及症状缓解时间等。结果：观察组显效率占比85.29%（29/34），有效率为94.12（32/34），均显著高于对照组的61.76%（21/34），70.59%（24/34）。差异均有统计学意义；两组治疗前PH、心率、PaO2、PaCO2均无明显差异，治疗后两组的PH、PaO2较治疗前显著提高，但观察组显著高于对照组，更接近正常水平；两组治疗后心率、PaCO2均显著降低，但观察组显著低于对照组，更接近正常水平；喘憋缓解、气促缓解、哮鸣音消失、湿啰音消失及咳嗽消失观察组相对于对照组比较明显缩短,差异均有统计学意义。结论：氧驱雾化吸入盐酸氨溴索治疗COPD急性加重期能增强疗效,缓解症状,缩短病程,提高疗效，值得临床推广。

Oxygen atomization inhalation of ambroxol hydrochloride in the treatment of COPD to observe the clinical curative effect of the patients with acute exacerbation

Objective To study oxygen atomization inhalation of ambroxol hydrochloride in the treatment of COPD to ob-serve the clinical curative effect of the patients with acute exacerbation. Methods From 2012 January to 2014 January, Our hospital treated 156 COPD patients with acute aggravating period, clinical trials were randomly selected 68 cases of the patients, with random data table divided into the observation group and the control group. 34 patients in each group, all the patients re-ceived conventional treatment of acute exacerbation of COPD, observation group on the basis of oxygen atomization inhalation of ambroxol hydrochloride in the treatment of. Comparative analysis of symptoms, blood gas analysis and curative effect of treat-ment group two patients with remission time etc. Results The observation group markedly effective rate accounted for 85.29%(29/34), effective rate was 94.12 (32/34), were significantly higher than those in control group 61.76%(21/34), 70.59%(24/34). The differences were statistically significant;there were no significant difference between the two groups before treatment PH, heart rate, PaO2, PaCO2, the two groups after treatment than before treatment PH, PaO2 increased significantly, but the observa-tion group was significantly higher than that in the control group, close to the normal level;the two groups after treatment of heart rate, PaCO2 decreased significantly, but the observation group was significantly lower than that of the control group, close to the normal level;out of harm, shortness of breath, alleviate alleviate wheeze disappeared, wet rales disappearance and cough disap-peared the observation group compared with the control group significantly reduced, the differences were statistically significant. Conclusion oxygen atomization inhalation of ambroxol hydrochloride in treatment of acute exacerbation of COPD can increase the curative effect, relieve symptoms, shorten the course of disease, improve the curative effect, is worth the clinical promotion.