| 万寿菊叶黄素的长期毒性研究 |
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| 引用本文： | 翟建英,;陈会丛,;张广平,;杨海润,;张思玉,;朱晓光,;蒋威,;解素花.万寿菊叶黄素的长期毒性研究[J].河南中医药学刊,2014(11):1608-1615. |
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| 作者姓名： | 翟建英 ;陈会丛 ;张广平 ;杨海润 ;张思玉 ;朱晓光 ;蒋威 ;解素花 |
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| 作者单位： | [1]北京中研同仁堂医药研发有限公司,中药复方新药开发国家工程研究中心北京100079; [2]北京同仁堂科技发展股份有限公司,北京100079 |
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| 基金项目： | 国家高技术研究发展计划（863计划）基金资助项目（编号：2010AA023006） |
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| 摘 要： | 目的：观察万寿菊叶黄素的长期毒性，为其安全应用提供参考。方法：将大鼠随机分为5组，空白对照组，溶媒对照组，叶黄素高剂量组57.0 mg·（kg·d）-1]、中剂量组23.5 mg·（kg·d）-1]、低剂量组5.7 mg·（kg·d）-1]，连续给药26周，停药4周，观察大鼠的一般行为、体质量增长、食量消耗、血液学及血液生化学指征、尿常规检查、系统尸解及组织病理学诊断。结果：长期毒性实验中，与同期溶媒对照组比较，叶黄素高剂量组、中剂量组、低剂量组动物行为活动、进食量等检查均未见异常；血液学指标、血液生化指标和尿液指标未发现与供试品有关的异常改变，病理组织学检查未发现与叶黄素相关的异常改变。结论：在本实验条件下，未观察到万寿菊叶黄素明显毒性反应，应用较安全。
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| 关 键 词： | 万寿菊叶黄素 长期毒性 大鼠 |
Study on Chronic Toxicity of Marigold Lutein |
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| Institution: | Zhai Jianying, Chen Huicong, Zhang Guangping, Yang Hairun, Zhang Siyu, Zhu Xiaoguang, Jiang Wei, Xie Suhua( 1. National Engineering Research Center for R＆D of TCM Multi-ingredient Drugs, Beijing China 100079 2. Tong Ren Tang Technologies Co. , Ltd. , Beijing China 100079) |
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| Abstract: | Objective：To study the chronic toxicity of Marigold Lutein in rats. Methods：Rats were randomly divided into control group,vehi-cle control group,high dose group（57. 0 mg·kg-1 ）,middle dose group（23. 5 mg·kg-1 ）and low dose group（5. 7 mg·kg-1 ）. Rats were given gavage for consecutive 26 weeks,and 4 weeks rest. The general conditions were observed and the related indexes were detec-ted,such as body weight,food consumption,blood,blood biochemistry,urine routine examination,autopsy and histopathologic diagnosis. Results：Compared with vehicle control group,no significant differences were observed in rat＆#39;s behaviors,food intake and relative exami-nation indexes,such as routine control of blood,blood biochemistry,urinalysis and organ coefficient. Conclusion：Marigold lutein is safe and has no side-effects in rats. |
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| Keywords: | marigold lutein chronic toxicity rats |
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