大黄对合并呼吸衰竭重症胰腺炎的治疗作用及对IL-6、CRP的影响

目的：观察大黄对合并呼吸衰竭重症胰腺炎（SAP）患者的治疗作用及对IL-6、CRP的影响。方法：将56例入住ICU伴呼吸衰竭的SAP患者分为大黄治疗组和对照组,观察2组患者氧合指数变化、机械通气天数、胃肠功能障碍持续时间、体温恢复时间及CRP、IL-6的变化。结果：2组患者第1、3天的血清CRP、IL-6水平相比无统计学差异（P〉0.05）;第5天血清CRP、IL-6水平大黄治疗组低于对照组（P〈0.05）,第7天,2组比较有统计学差异（P〈0.01）。第1、3、5、7天PaO2/FiO2大黄治疗组高于对照组,2组相比有统计学差异（P〈0.05）。大黄治疗组胃肠功能恢复所需时间与对照组比较,有统计学差异（P〈0.01）;体温恢复时间大黄组与对照组相比,有统计学差异（P〈0.05）;机械通气时间大黄治疗组与对照组比较有统计学差异（P〈0.01）。结论：大黄可有效改善胃肠功能障碍并减弱炎症反应,抑制炎症因子释放,并能加速肺损伤的恢复,减少机械通气时间。

Therapeutic Effects of DaHuang on Severe Acute Pancreatitis Complicated with Respiratory Failure and Its Impact on Expressions of IL-6 and CRP

Objective： To approach therapeutic effects of DaHuang（Rhubarb） for patients with severe acute pancreatitis（SAP） complicated with respiratory failure and its impact on expressions of IL-6 and CRP.Method： All 56 patients were randomly divided into treatment group of DaHuang and control group.Changes of CRP and IL-6,recovery time of body temperature,duration of gastrointestinal disorder,days of mechanical ventilation and changes of oxygenation index of patients were observed.Result： Comparisons between both groups demonstrated no statistical difference in the levels of CRP and IL-6 in serum at the 1st and 3rd day（P0.05）;levels of CRP and IL-6 of treatment group were lower than that of control group at the 5th day（P0.05）,comparison between both groups at the 7th day showed statistical difference（P0.01）.Treatment group was higher than control group in PaO2/FiO2 at the 3rd,5th and 7th day,comparisons between both groups had statistical difference（P0.05）.Comparisons between both groups showed significant difference in recovery time of gastrointestinal function（P0.05）;statistical difference also existed in time of mechanical ventilation（P0.01）.Conclusion： DaHuang could effectively improve gastrointestinal disorder,alleviate inflammatory reactions,inhibit the release of cytokines,accelerate the recovery of pulmonary injury and reduce the time of mechanical ventilation.