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地黄饮子对β淀粉样蛋白所致PC12细胞损伤的保护作用
引用本文:周妍妍,谢宁,姚辛敏,何秀丽.地黄饮子对β淀粉样蛋白所致PC12细胞损伤的保护作用[J].中医药学报,2010,38(2):19-21.
作者姓名:周妍妍  谢宁  姚辛敏  何秀丽
作者单位:黑龙江中医药大学,黑龙江,哈尔滨,150040
基金项目:国家自然科学基金,高等学校博士学科点专项科研基金资助项目 
摘    要:目的:观察地黄饮子对β淀粉样蛋白(Aβ25-35)诱导的PC12细胞损伤的保护作用。方法:通过HE染色、尼氏染色、电镜观察地黄饮子对细胞形态的影响。结果:地黄饮子可显著改善Aβ25-35损伤引起的PC12细胞形态的改变,减轻细胞膜的损伤,减少损伤所致的细胞死亡。结论:地黄饮子对Aβ25-35所致PC12细胞损伤具有较好的保护作用。

关 键 词:β淀粉样蛋白  PC12细胞  老年性痴呆  地黄饮子

The Effect of DHYZ in Treating the Injury of PC12 Induced by Amyloid Beta-Protein
ZHOU Yan-yan,XIE Ning,YAO Xin-min,HE Xiu-li.The Effect of DHYZ in Treating the Injury of PC12 Induced by Amyloid Beta-Protein[J].Acta Chinese Medicine and Pharmacology,2010,38(2):19-21.
Authors:ZHOU Yan-yan  XIE Ning  YAO Xin-min  HE Xiu-li
Institution:ZHOU Yan-yan,XIE Ning,YAO Xin-min,HE Xiu-li (Helongjiang university of Chinese medicine,Harbin 150040,China)
Abstract:Objective:To investigate the effect of decoction of Rehmanniae on the injury of PC12 cell induced by Aβ(β-amyloid protein). Methods: To investigate the change of conformation by HE Staining,Nissl's Staining and Electron microscope. Results: Decoction of Rehmanniae can prominently improve the conformation change of injurious PC12 cell, improve the cell energy,and reduce the injurious cellto death. Conclusion: Decoction of Rehmanniae canprotect the injurious cell.
Keywords:β-amyloid protein  PC12 cell  Alzheimer'disease  Decoction of Rehmanniae
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