复方玄驹胶囊治疗膝骨关节炎的临床研究

目的:观察复方玄驹胶囊治疗膝骨关节炎的临床疗效及安全性,并运用健康调查问卷SF-36(中文版)全面客观评价其对膝骨关节炎患者生存质量的改善程度。方法:按照诊断标准选择57例膝骨关节炎患者,随机分为治疗组及对照组,治疗组服用复方玄驹胶囊,每粒0.42g,4粒/次,3次/d,对照组口服塞来昔布,0.2g/次,1次/d,均饭后口服,连续服用6周。观察两组治疗前后总体疗效、WOMAC积分及国际通用的SF-36(中文版)健康调查问卷8个维度的变化。结果:两组治疗后优良率和有效率分别为48.2%、82.7%和42.7%、89.3%,且两组治疗前后WOMAC积分包括疼痛、关节僵硬及功能障碍指数治疗后均有明显改善。两组治疗前后生存质量调查生理功能、生理职能、躯体疼痛、活力、情感职能、精神健康和健康变化均有明显改善(P0.05),治疗组在生理功能、情感职能、活力、精神健康各维度均优于对照组(P0.05)。结论:复方玄驹胶囊治疗膝骨关节炎疗效显著,并能明显提高膝关节炎的生存质量。

The Clinical Research on Compound Xuanju Capsule for the Treatment of Knee Osteoarthritis

Objective：This paper is to observe the clinical effects and safety of Compound Xuanju Capsule for the treat- ment of knee osteoarthritis and objectively appraises its improvements in the quality of life of patients with knee osteoar- thritis by using SF- 36 （Chinese Version） health questionnaire survey. Method：Choose 57 patients with knee osteoar- thritis according to diagnostic criteria, and randomly divide them into treatment group and control group respectively. The treatment group take Compound Xuanju Capsule by 0. 42g/grain, 4 grains/time, 3 times/day; and the control group take Celecoxib, 0. 2g/time, 1 time/day. Both of the groups take by oral use continuously for six weeks. Observe the overall effect, WOMAC index and the changes of eight indexes in international used SF - 36 （ Chinese Version） health questionnaire survey before and after treatment. Result：The good effective rate and effective rate after treatment of the two groups were 48.2% ,82. 7% and 42.7% ,89.3% respectively, but the WOMAC index, including pain, stiff joints and dysfunction index, all had clear improvements after treatment. The quality of patients＇ life from the two groups, including physiological function, role physical, psychological pain, vigor, sensibility function, mental health and health change, also all had clear improvements （ P 〈 0. 05 ） after treatment. The physiological function, sensibility function, vigor and metal health in treatment group were obviously better than that in control group （P 〉 0. 05 ）. Conclu- sion：The Compound Xuanju Capsule is effective in the treatment of knee osteoarthritis, and it can obviously raise the quality of patients＇life.