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虎杖功效成分组研究V-血沉沉降速率谱效关系研究
引用本文:李强,夏晓晖,雷海民,肖洪彬,宋玉超.虎杖功效成分组研究V-血沉沉降速率谱效关系研究[J].中医药学报,2011,39(5).
作者姓名:李强  夏晓晖  雷海民  肖洪彬  宋玉超
作者单位:1. 北京中医药大学中药学院,北京,100102
2. 北京双鹤药业研究院,北京,100102
3. 黑龙江中医药大学基础医学院,黑龙江哈尔滨,150040
基金项目:国家自然科学基金青年基金(No.30701083); 高等学校博士学科点专项科研基金(No.20070026021)
摘    要:目的:在HPLC指纹图谱和血沉沉降速率的基础上进行谱效分析,以此确定虎杖影响急性血瘀大鼠血沉沉降速率药效的“功效成分组”.方法:采用偏最小二乘回归法,对虎杖HPLC指纹图谱数据和血沉沉降速率数据之间的内在联系进行谱效分析.结果:指纹图谱上的X3、X4、X5、X17、X18这5个成分组成的“功效成分组”对虎杖影响血沉沉降速率药效的贡献较大.结论:中医用药基于正确的辨证论治,是根据中药的功效对患者进行治疗,因此,反映中药功效的“功效成分组”是评价中药质量的关键,“功效成分组”需最终得到药效验证才具有代表性.

关 键 词:虎杖  偏最小二乘回归  谱效分析  HPLC  血沉沉降速率

Effective Compositions of Polygoni Cuspidati (V) :Study on Spectrum- effect Relationship of Dlood Sedimentation Rate
LI Qiang,XIA Xiao-hui,LEI Hai-min,XIAO Hong-bin,SONG Yu-chao.Effective Compositions of Polygoni Cuspidati (V) :Study on Spectrum- effect Relationship of Dlood Sedimentation Rate[J].Acta Chinese Medicine and Pharmacology,2011,39(5).
Authors:LI Qiang  XIA Xiao-hui  LEI Hai-min  XIAO Hong-bin  SONG Yu-chao
Institution:LI Qiang1,XIA Xiao-hui2,LEI Hai-min1,XIAO Hong-bin3,SONG Yu-chao1(1.Beijing University of Chinese Medicine,Beijing 100102,China,2.Insititute of Beijing Double-crane Pharmaceutical CO.LTD,3.Heilongjiang University of Chinese Medicine,Harbin 150040,China)
Abstract:Objective:To study the fingerprints correlated with pharmacodynamics on the basis of HPLC fingerprint and the Blood Sedimentation rate of acute blood stasis rats in order to identify the effective compounds of the blood sedimentation rate potency of acute blood stasis rats.Method:Studied the inherent connections between HPLC fingerprint and the blood sedimentation rate potency of acute blood stasis rats of polygonum cuspidatum with the method of the partial least squares regression(PLSR).Result:Effective co...
Keywords:Polygoni cuspidati  Partial least square method  Spectrum-effect relationship HPLC  Blood sedimentation rate  
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