| Box—Behnken效应面法优化淫羊藿配方颗粒提取工艺 |
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| 引用本文： | 谢蓉,李思维,王梅,郭东艳,宋忠兴,唐志书.Box—Behnken效应面法优化淫羊藿配方颗粒提取工艺[J].现代中医药,2012,32(5):71-75. |
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| 作者姓名： | 谢蓉 李思维 王梅 郭东艳 宋忠兴 唐志书 |
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| 作者单位： | 1. 陕西中医学院,陕西咸阳,712046
2. 陕西中医学院附属医院,陕西咸阳,712000 |
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| 基金项目： | 国家十二五“重大新药创制”科技重大专项(2011ZX09401-308-037);陕西省科技统筹创新工程计划项目(2011KTCL03-05);陕西省教育厅产业化中试项目(2010JC05) |
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| 摘 要： | 目的优化淫羊藿配方颗粒的提取工艺。方法采用单因素试验结合Box—Behnken效应面分析法，以出膏率、淫羊藿苷含量为评价指标，考察提取时间、加水量、提取次数等因素对提取工艺的影响。结果优选提取工艺为：22倍量水，煎煮提取2次，每次36min，淫羊藿苷含量可达10．16mg·g^-1，出膏率为17．26％。结论Box—Be-hnken试验设计法用于淫羊藿配方颗粒提取工艺的优选是可行的，数学模型的预测值与试验观察值相符。
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| 关 键 词： | 淫羊藿配方颗粒 淫羊藿苷 Box—Behnken设计 提取工艺 |
Optimization of the Extraction Technique of Herba Epimedii with Central Composite Design and Response surface method |
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| Xie Rong
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Li Siwei
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Wang Mei
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Guo Dongyan
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Song Zhongxing
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Tang Zhishu.Optimization of the Extraction Technique of Herba Epimedii with Central Composite Design and Response surface method[J].Modern Traditional Chinese Medicine,2012,32(5):71-75. |
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| Authors: | Xie Rong Li Siwei Wang Mei Guo Dongyan Song Zhongxing Tang Zhishu |
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| Institution: | 1(1.Shaanxi University of Traditional Chinese Medicine,Xianyang,Shaanxi 712046; 2.The Affiliated Hospital of shaanxi university of Traditional Chinese Medicine,Xianyang,Shaanxi 712000) |
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| Abstract: | Objective To optimize extracting technology of herba epimedii formula granules.Methods Based on the results of single-factor-at-a-time-technique,Box-Behnken experimental design combined with response surface methodology(RSM) was employed,with the extraction time(A),the water addition(B),the extraction(C) as the independent variables.The response variable were the dried extraction yield and the content of Icariin.ResultsThe optimum extraction conditions were to reflux for 2 times with 22 fold water and each time for 36 min.The content of Icariin was 10.16mg·g-1,and the dried extraction yield was 17.26 %.Conclusions Box-Behnken design is suitable for optimizing the extraction technique of Herba Epimedii formula granules.The observed responses were in close agreement with the predicted values of the mathematic models. |
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| Keywords: | Herba Epimedii formula granules Icariin Box-Behnken design Extraction technology |
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