| 黄连解毒汤对自发性高血压大鼠血管内皮功能的保护作用 |
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| 引用本文： | 张志伟,岳桂华.黄连解毒汤对自发性高血压大鼠血管内皮功能的保护作用[J].时珍国医国药,2011,22(5):1071-1073. |
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| 作者姓名： | 张志伟 岳桂华 |
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| 作者单位： | 广西中医学院附属瑞康医院,广西,南宁,530011 |
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| 基金项目： | 广西壮族自治区自然科学基金 |
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| 摘 要： | 目的观察黄连解毒汤对自发性高血压大鼠(Spontaneously hypertensive rats,SHR)血管内皮功能的保护作用。方法 24只12周龄雄性SHR随机分为黄连解毒汤组、卡托普利组和模型组3组,8只同龄雄性Wistar-Kyoto(WKY)大鼠为空白对照组,通过BP-6动物无创血压测试仪测定各组治疗前血压,连续给药6周,1次/d,第1,2,4,6周的第7天下午定时测量各组血压,6周后由腹主动脉取血,检测血清血栓素A2(TX-A2)、6酮前列环素(6-K-PG)、一氧化氮(NO)、内皮素-1(ET-1)、超氧化物歧化酶(SOD)、丙二醛(MDA)、血管紧张素Ⅱ(ANG-Ⅱ)和血管性血友病因子(vWF)。结果黄连解毒汤和卡托普利均可降低SHR血压、TX-A2、ET-1、MDA、ANG-Ⅱ和vWF,增加6-K-PG、NO和SOD。结论黄连解毒汤可降低SHR的血压,且对血管内皮功能具有保护作用。
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| 关 键 词： | 黄连解毒汤 自发性高血压大鼠 内皮素-1 超氧化物歧化酶 |
Protective Effects of Huanglianjiedu - Decoction on Function of Blood Vessel Endothelium in Spontaneous Hypertension Rats(SHR) |
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| ZHANG Zhi-wei,YUE Gui-hua.Protective Effects of Huanglianjiedu - Decoction on Function of Blood Vessel Endothelium in Spontaneous Hypertension Rats(SHR)[J].Lishizhen Medicine and Materia Medica Research,2011,22(5):1071-1073. |
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| Authors: | ZHANG Zhi-wei YUE Gui-hua |
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| Institution: | ZHANG Zhi-wei,YUE Gui-hua*(Affiliated Ruikang Hospital,Guangxi TCM University,Nanning,530011,China) |
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| Abstract: | Objective To observe the effects of Huanglianjiedu-Decoction on function of blood vessel endothelium in spontaneous hypertension rats(SHR).Methods Twenty-four SHR were randomly divided into Huanglianjiedu-Decoction-treated group,captopril-treated group and model group;eight Wistar-Kyoto rats were used as blank group.The rats were treated by Huanglianjiedu-Decoction,captopril and distilled water respectively for six weeks.Blood pressure(BP) was measured at the beginning of the experiment and the end of every... |
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| Keywords: | Huanglianjiedu-Decoction Spontaneous Hypertension Rats Endothelin-1 Superoxide dismutase |
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