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| 安心对垂体后叶素所致实验性心肌缺血的保护作用 | |
| 引用本文： | 王智文,洪铁,杨振.安心对垂体后叶素所致实验性心肌缺血的保护作用[J].时珍国医国药,2007,18(1):81-82. |
| 作者姓名： | 王智文 洪铁 杨振 |
| 作者单位： | 1. 吉林大学药学院,吉林,长春,130021 2. 吉林大学药学院,吉林,长春,130021;吉林省中医中药研究院,吉林,长春,130021 3. 吉林省中医中药研究院,吉林,长春,130021 |
| 摘 要： | 目的观察安心改善心肌缺血的作用。方法采用垂体后叶素(PIT)所致大鼠心肌缺血模型,监测标准Ⅱ导联心电图;小鼠腹腔注射PIT,测定血清脂质过氧化产物丙二醛(MDA)含量及超氧化物歧化酶(SOD)以及磷酸肌酸激酶(CK)和乳酸脱氢酶(LDH)的活性。结果安心能明显缓解PIT所致大鼠心电图T波的改变。在PIT所致小鼠心肌缺血模型中,安心能增加SOD的活性,降低血清LDH,CK,MDA的活性。结论安心对PIT所致的心肌缺血有较好的保护作用。 |
| 关 键 词： | 安心 心肌缺血 垂体后叶素 |
| 文章编号： | 1008-0805(2007)01-0081-02 |
| 修稿时间： | 2006年6月11日 |
Protective Effect of Anxin on Pituitrin -induced Myocardial Ischemic Injury |
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| WANG Zhi-wen,HONG Tie,YANG Zhen.Protective Effect of Anxin on Pituitrin -induced Myocardial Ischemic Injury[J].Lishizhen Medicine and Materia Medica Research,2007,18(1):81-82. | |
| Authors: | WANG Zhi-wen HONG Tie YANG Zhen |
| Institution: | WANG Zhi-wen~1,HONG Tie~ |
| Abstract: | Objective To observe protective effects of Anxin,a complex of Chinese medicine,on myocardial ischemic injury. Methods The electrocardiograph(ECG) was observed in myocardial ischemia rats induced by pituitrin(PIT) through lingual vein;the contents of MDA,SOD,CK and LDH in serum were assayed,respectively,in myocardial ischemia mice which pituitrin was peritoneal injected.Results High(2.8 g/kg),medium(1.4 g/kg) dose of Anxin could obviously relieve the ECG changes caused by pituitrin-induced myocardial ischemia in rats.The threshold dose of Anxin(4 g/kg,2 g/kg)decreased CK,LDH,MDA production and increased SOD activity in the serum of mice.Conclusion Anxin possesses the protective effect on myocardial ischemia induced by PIT. |
| Keywords: | Anxin Myocardial ischemia Pituitrin |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |