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大黄黄连泻心汤、理中丸对消炎痛型及水浸应激型胃溃疡寒热证模型大鼠血清NO和ET含量的影响
引用本文:李冀,谢田,于海,蒋蕾,柴剑波,赵伟国,毕珺辉.大黄黄连泻心汤、理中丸对消炎痛型及水浸应激型胃溃疡寒热证模型大鼠血清NO和ET含量的影响[J].时珍国医国药,2011,22(8):1862-1864.
作者姓名:李冀  谢田  于海  蒋蕾  柴剑波  赵伟国  毕珺辉
作者单位:黑龙江中医药大学,黑龙江哈尔滨,150040
基金项目:国家“十一五”科技支撑计划项目
摘    要:目的探讨消炎痛型及水浸应激型胃溃疡中医寒热证模型的形成机制,以及寒热方剂对胃溃疡寒热证模型的基本作用机理和方证相应的客观规律。方法采用寒热因素结合腹腔注射消炎痛法和水浸应激法,分别建立大鼠胃溃疡寒、热证模型,用酶联免疫法检测大黄黄连泻心汤、理中丸对受试大鼠血清中NO和ET含量的影响。结果 NO在水浸应激型胃溃疡和消炎痛型溃疡寒证中含量降低,在热证中含量明显升高(P<0.05或P<0.01)。大黄黄连泻心汤可显著降低热性溃疡组大鼠血清NO的含量,理中丸可显著升高寒性溃疡组大鼠血清NO的含量(P<0.05或P<0.01)。水浸应激型和消炎痛型溃疡寒证中ET含量升高,热性方剂理中丸能降低ET含量。结论 通过"方证相应"理论验证了"病证结合"的胃溃疡寒热模型复制成功。大黄黄连泻心汤对水浸应激型胃溃疡热证、理中丸对水浸应激型胃溃疡寒证的预防作用,及二者对消炎痛型胃溃疡的治疗作用,可通过调节大鼠血清中NO的水平,降低ET的含量而实现。

关 键 词:大黄黄连泻心汤  理中丸  寒热证  胃溃疡  消炎痛  水浸应激  一氧化氮  内皮素

Influence of Dahuang Huanglian Xiexin Decoction and Lizhong Pill on NO and ET Contents in Serum of Gastric Ulcer Model Rats Induced by Indomethacin or Water Immersion Stress Combined with Cold or Heat Syndrome
LI Ji,XIE Tian,YU Hai,JIANG lei,CHAI Jian-bo,ZHAO Wei-guo,BI Jun-hui.Influence of Dahuang Huanglian Xiexin Decoction and Lizhong Pill on NO and ET Contents in Serum of Gastric Ulcer Model Rats Induced by Indomethacin or Water Immersion Stress Combined with Cold or Heat Syndrome[J].Lishizhen Medicine and Materia Medica Research,2011,22(8):1862-1864.
Authors:LI Ji  XIE Tian  YU Hai  JIANG lei  CHAI Jian-bo  ZHAO Wei-guo  BI Jun-hui
Institution:LI Ji,XIE Tian,YU Hai,JIANG lei,CHAI Jian-bo,ZHAO Wei-guo,BI Jun-hui*(Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China)
Abstract:Objective To explore the mechanism of gastric ulcer model induced by indomethacin or water immersion stress combined with cold or heat syndrome,and to observe the basic and objective regularity of formula-syndrome corresponding of cold or heat formula on gastric ulcer model with cold or heat syndrome.Methods Adopting cold or heat factors combined with indomethacin injection into abdominal cavity or water immersion stress method to establish gastric ulcer model with cold and heat syndrome.Using ELISA to dete...
Keywords:Dahuang Huanglian Xiexin Decoction  Lizhong Pill  Cold or Heat  Syndrome  Gastric Ulcer  Indomethacin  Water Immersion Stress  NO  ET  
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