| 辛通畅络法干预局灶节段性肾小球硬化大鼠细胞外基质积聚的实验研究 |
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| 引用本文： | 窦一田,任桐,曹式丽.辛通畅络法干预局灶节段性肾小球硬化大鼠细胞外基质积聚的实验研究[J].时珍国医国药,2011,22(9). |
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| 作者姓名： | 窦一田 任桐 曹式丽 |
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| 作者单位： | 1. 天津中医药大学,天津,300193
2. 天津中医药大学第一附属医院,天津,300192 |
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| 摘 要： | 目的 观察辛通畅络法对局灶节段性肾小球硬化(FSGS)大鼠肾小球细胞外基质(ECM)增殖的影响.方法 阿霉素注射法诱发FSGS型阿霉素肾病大鼠模型,以辛通畅络法的载体中药复方肾苏Ⅱ为治疗药物,贝那普利为对照药物进行干预.于治疗第12周末,切取肾脏进行病理学观察及免疫组化检测,现察肾小球硬化、基质积聚程度及其主要成分表达.结果 病理学观察及免疫组化检测显示,中、西药组均出现肾小球硬化进展减缓,基质增殖抑制,FN、LN及ColⅣ表达降低,且中药组具干预优势.结论 辛通畅络法可通过抑制FSGS大鼠肾小球ECM的过度积聚,延缓其肾小球硬化进展.
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| 关 键 词： | 局灶节段性肾小球硬化 辛通畅络法 肾苏Ⅱ 细胞外基质 |
Effects of Dredging Vessels by Xintong on Mesangial Matrix Proliferation in FSGS Rat Glomerulus |
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| DOU Yi-tian,REN Tong,CAO Shi-li.Effects of Dredging Vessels by Xintong on Mesangial Matrix Proliferation in FSGS Rat Glomerulus[J].Lishizhen Medicine and Materia Medica Research,2011,22(9). |
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| Authors: | DOU Yi-tian REN Tong CAO Shi-li |
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| Institution: | DOU Yi-tian1,REN Tong2,CAO Shi-li2(1.Tianjin University of Traditional Chinese Medicine(TCM),Tianjin 300193,China,2.The First Hospital Attached to Tianjin University of TCM,TianJin 300192,China) |
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