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| 黄萸方防治大鼠早期糖尿病肾病足细胞损伤的研究 | |
| 引用本文： | 李佑生,杨磊,王文健,刘毅,何燕铭,陈伟华,应健.黄萸方防治大鼠早期糖尿病肾病足细胞损伤的研究[J].时珍国医国药,2012,23(2):299-301. |
| 作者姓名： | 李佑生 杨磊 王文健 刘毅 何燕铭 陈伟华 应健 |
| 作者单位： | 1. 暨南大学第二临床医学院/深圳市人民医院,广东深圳,518020 2. 复旦大学中西医结合研究所复旦大学附属华山医院,上海,200040 3. 上海中医药大学附属岳阳中西医结合医院,上海,200437 |
| 摘 要： | 目的 观察中药复方黄萸方对实验性糖尿病大鼠微量白蛋白尿的疗效,及对足细胞的影响.方法 采用高糖高脂喂饲加低剂量STZ诱导伴胰岛素抵抗的大鼠2型糖尿病,给予黄萸方治疗12周,观察血糖及尿微量白蛋白,采用透射电镜及图像分析技术,观察对足细胞形态的影响.结果 黄萸方可降低血糖、减少尿微量白蛋白,同时可改善足细胞损伤,疗效优于ARB.结论 黄萸方可改善实验性大鼠2型糖尿病肾脏病变,主要是改善足细胞损伤,减少微量白蛋白尿. |
| 关 键 词： | 黄萸方 糖尿病肾病 微量白蛋白尿 胰岛素抵抗 足细胞 |
Effect of Huang -Yu Fang on Podocyte Damage in Early Diabetic Nephropathy Rats |
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| LI You-sheng , YANG Lei , WANG Wen-jian , LIU Yi , HE Yan-ming , CHEN Wei-hua , YING Jian.Effect of Huang -Yu Fang on Podocyte Damage in Early Diabetic Nephropathy Rats[J].Lishizhen Medicine and Materia Medica Research,2012,23(2):299-301. | |
| Authors: | LI You-sheng YANG Lei WANG Wen-jian LIU Yi HE Yan-ming CHEN Wei-hua YING Jian |
| Institution: | 1.The Second Clinical Medical College of Jinan University /Shenzhen People’s Hospital,Shenzhen 518020,China;2.Institute of Integrative Medicine,Fudan University/ Hua Shan Hospital Affiliated to Fudan University Shanghai 200040,China 3.Yue Yang Hospital of Integrative Medicine Affiliated to Shanghai University of Traditional Chinese Medicine,Shenzhen 200437,China) |
| Abstract: | Objective To explore the effect of Huang-Yu Fang(HYF) on urinary micro-albumin in experimental early diabetic rats,especially on podocyte damage. Methods Rats were fed a high glucose and high fat diet and given a low dose of STZ to develop type 2 diabetes with insulin resistance,and then treated with HYF 12 weeks.Blood glucose,urinary micro-albumin and other targets were measured,as well as the morphology of podocytes were observed by transmission electron microscope. Results HYF could decrease blood glucose level,reduce urinary micro-albumin,and ameliorate the reduction of podocyte number and the podocytes fusion.These effects were better than ARB. Conclusion HYF has beneficial renoprotective effect on progression of type 2 diabetic nephropathy in rats,and the main effect is ameliorating the reduction of podocyte number and the podocytes fusion,and reducing urinary micro-albuminuria. |
| Keywords: | Huang-Yu Fang Diabetic nephropathy Microalbuminuria Insulin resistance Podocyte |
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