| 蜗牛多糖的提取和免疫学活性研究 |
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| 引用本文： | 湛孝东,王克霞,李朝品,康栗.蜗牛多糖的提取和免疫学活性研究[J].时珍国医国药,2006,17(11):2191-2192. |
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| 作者姓名： | 湛孝东 王克霞 李朝品 康栗 |
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| 作者单位： | 1. 安徽理工大学医学院,安徽,淮南,232001
2. 安徽淮南朝阳医院,安徽,淮南,232007 |
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| 摘 要： | 目的提取蜗牛多糖并研究其免疫学活性。方法用碱提醇沉法从江西巴蜗牛中提取多糖,通过溶血空斑实验、巨噬细胞吞噬功能实验、迟发型变态反应和小鼠脾淋巴细胞转化实验研究蜗牛多糖的免疫学活性。结果蜗牛多糖显著增强小鼠溶血空斑形成,提高小鼠巨噬细胞吞噬指数,增强小鼠迟发型变态反应,显著提高小鼠脾淋巴细胞转化率,且有良好的量-效关系。结论蜗牛多糖能提高小鼠的非特异性和特异性细胞免疫功能。
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| 关 键 词： | 蜗牛多糖 提取 免疫学活性 |
| 文章编号： | 1008-0805（2006）11-2191-02 |
| 收稿时间： | 2006-01-11 |
| 修稿时间： | 2006-05-26 |
Extraction of Snail Polysaccharides and its Immunologic Study |
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| ZHAN Xiao-dong,WANG Ke-xia,LI Chao-pin,KANG Li.Extraction of Snail Polysaccharides and its Immunologic Study[J].Lishizhen Medicine and Materia Medica Research,2006,17(11):2191-2192. |
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| Authors: | ZHAN Xiao-dong WANG Ke-xia LI Chao-pin KANG Li |
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| Institution: | 1. School of Medicine, Anhui University of Science and Technology, Huainan 232001, China ; 2. Anhui Hua inan Chaoyang Hospital, Huainan 232007, China |
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| Abstract: | ObjectiveTo extract Snail polysaccharides(SP) and study their immunologic activity.MethodsPolysaccharides were extracted from Bradybaena kiangsiensis by alkali method and effects of SP on immunity were investigated by haemolytic plaque assay,macrophage function assay,delayed type hypersensitivity reaction and splenic lymphocyte transformation assay in mice.ResultsSP strikingly increased haemolytic plaque,promoted macrophage function,enhanced delayed type hypersensitivity reaction,and remarkably raised splenic lymphocyte transformation efficiency in a dose-dependent manner.ConclusionSP is able to enhance immunity. |
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| Keywords: | Snail polysaccharides Extraction Immunologic Activity |
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