蒙药乳腺-Ⅰ号对实验性乳腺增生大鼠血脂及血清性激素水平的影响

目的观察蒙药乳腺-I号对实验性乳腺增生大鼠血脂代谢及血清性激素水平的影响。方法将大鼠随机分为两组:正常对照组和疾病模型组。模型组通过肌肉注射雌激素和孕激素的方法复制大鼠乳腺增生模型。将乳腺增生大鼠随机分为三苯氧胺组,蒙药乳腺-I号低、高剂量组,模型组。各组大鼠连续给药30 d后测定体质量、第2对乳头直径,检测血清血脂水平及血清激素水平,取乳腺组织做组织病理学观察。结果蒙药乳腺-I号组大鼠乳头直径明显小于模型组。模型组与正常对照组比较,大鼠血清TC、TG、LDL-c明显升高(P<0.05或P<0.01),血清P、T含量明显降低(P<0.01),PRL显著升高(P<0.05)。蒙药乳腺-I号组与模型组比较大鼠血清TC、TG、LDL-c、E2显著降低(P<0.05或P<0.01),FSH显著升高(P<0.01),且有一定的量效关系。镜下可见蒙药乳腺I号组乳腺小叶数及小叶腺泡数均少于模型组,乳腺腺泡数目及腔内分泌物较少,部分可接近正常大鼠的乳腺结构腺泡。结论蒙药乳腺-I号对实验性大鼠乳腺增生具有明显的治疗作用,对乳腺增生大鼠血脂水平及激素水平具有明显的调节作用。

Effects of Mongolian Medicine Mammary Gland Ⅰ on the Metabolism of Serum Lipids in Rats with Hyperplasia of Mammary Glands

ObjectiveTo observe the effects of Mongolian medicine Mammary GlandⅠ on the metabolism of serum lipids in rats with hyperplasia of mammary glands. MethodsAdult female wistar rats were randomly divided into 2 groups:control group and disease model group.Disease model group rats were injected intramuscular with E2 and P to establish rat model of hyperplasia of mammary glands.Then disease model group was randomly subdivided into 4 groups:tamoxifen group,small and large dose of Mammary-I group and model group.Different groups were respectively treated with tamoxifen,small and large doses of Mammary Gland-Ⅰ,distilled water for 30 days.Then the weight and the diameter of teats were measured,the levels of serum lipids and serum hormone were measured. ResultsMammary Gland-Ⅰcould decrease the diameter of increased teats.Compared with control group,the serum levels of TC,TG,LDL-c and PRL in model group were obviously increased(P<0.05,P<0.01) and the serum levels of P,T were obviously decreased(P<0.01).Compared with model group,the serum levels of TC,TG,LDL-C and E2 in each dose of Mammary Gland-Ⅰgroup were obviously reduced,and FSH was obviously elevated(P<0.01). ConclusionMammary Gland-I has significant effect on the metabolism of serum lipids in hyperplasia of mammary gland.