| 大蓟醇提物对两肾一夹高血压大鼠Intermedin变化的影响 |
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| 引用本文： | 梁颖,黎济荣,周永忠,闫琳,赵迅霞,贾月霞.大蓟醇提物对两肾一夹高血压大鼠Intermedin变化的影响[J].时珍国医国药,2011,22(7):1572-1574. |
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| 作者姓名： | 梁颖 黎济荣 周永忠 闫琳 赵迅霞 贾月霞 |
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| 作者单位： | 1. 宁夏医科大学病理生理学系,宁夏,银川,750004
2. 宁夏医科大学基础医学实验中心,宁夏,银川,750004 |
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| 摘 要： | 目的探讨大蓟提取物对两肾一夹(2-kidney1-clip,2K1C)高血压大鼠Intermedin(IMD)变化的影响。方法采用2K1C复制肾性高血压大鼠模型;检测心功能、左心重与体重比值(LVM/BW)及右肾重与左肾重比值(RK/LK);免疫组化法检测心脏、肾脏和腹主动脉IMD的水平;放射免疫学方法检测血浆中IMD和血管紧张素Ⅱ(angiotensinⅡ,AngⅡ)的含量;采用硝酸还原酶法测定血清中一氧化氮(nitric oxide,NO)含量,Griess化学比色法测定血清中一氧化氮合酶(nitric ox-ide sythase,NOS)活性的变化。结果与正常组相比,模型组大鼠心功能抑制,RK/LK和LVM/BW比值升高,心脏、肾脏和腹主动脉IMD的水平及血浆中IMD和AngⅡ的含量升高,血清中NO和NOS的含量降低;与模型组相比,大蓟组大鼠心功能明显增强,RK/LK和LVM/BW比值及血浆中AngⅡ的含量降低,心脏、肾脏和腹主动脉IMD的水平升高,血浆中IMD的含量、血清中NO和NOS的含量升高,差异均有显著性。结论大蓟通过增加IMD的含量激活NO/NOS对肾性高血压有降压作用。
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| 关 键 词： | Intermedin 大蓟 两肾一夹 一氧化氮 一氧化氮合酶 |
Effect of Daji Alcohol Extract on the Change of Intermedin in Two Kidney-one Clip Hypertensive Rats |
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| LIANG Ying,LI Ji-rong,ZHUO Yong-zhong,YAN Lin,ZHAO Xun-xia,JIA Yue-xia.Effect of Daji Alcohol Extract on the Change of Intermedin in Two Kidney-one Clip Hypertensive Rats[J].Lishizhen Medicine and Materia Medica Research,2011,22(7):1572-1574. |
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| Authors: | LIANG Ying LI Ji-rong ZHUO Yong-zhong YAN Lin ZHAO Xun-xia JIA Yue-xia |
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| Institution: | LIANG Ying1,LI Ji-rong1,ZHUO Yong-zhong2,YAN Lin2,ZHAO Xun-xia2,JIA Yue-xia1(1.Pathophysiological Department,Ningxia Medical University,Yinchuan,750004,China,2.Basic Medical Experimental Center,China) |
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| Abstract: | ObjectiveTo approach the effect of Daji alcohol extract on the change of intermedin(IMP) in two kidney-one clip hypertensive rats.MethodsThe renal hypertensive model in rats was established by two kidney-one clip.Heart function,the ratio of left ventricular mass to body weight(LVM/BW),and the ratio of right kidney weight to left kidney(RK/LK) were tested.The IMD level of heart,kidney and abdominal aorta were tested by immunohistochemistry method.Radiation immunological method was used to detect plasma level... |
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| Keywords: | Intermedin |
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