| 石榴皮中鞣质和黄酮类化合物抑菌作用的实验研究 |
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| 引用本文： | 杨林,周本宏.石榴皮中鞣质和黄酮类化合物抑菌作用的实验研究[J].时珍国医国药,2007,18(10):2335-2336. |
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| 作者姓名： | 杨林 周本宏 |
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| 作者单位： | 1. 三峡大学护理学院,湖北,宜昌,443000;武汉大学药学院,湖北,武汉,430072
2. 武汉大学药学院,湖北,武汉,430072 |
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| 基金项目： | 国家自然科学基金资助项目(No.30570182) |
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| 摘 要： | 目的探讨石榴皮中鞣质和黄酮类化合物的体外抑菌活性效果并确认其有效部位。方法提取两种化合物,采用试管两倍稀释法对金黄色葡萄球菌、福氏痢疾杆菌、沙门氏菌、大肠杆菌、绿脓杆菌和白色念珠菌进行体外抑菌实验。结果石榴皮中鞣质类化合物对金黄色葡萄球菌、福氏痢疾杆菌、沙门氏菌、大肠杆菌、绿脓杆菌和白色念珠菌均有不同程度的抑菌作用,而黄酮类化合物对绿脓杆菌和白色念珠菌抑菌效果不强。结论石榴皮中鞣质和黄酮类化合物有一定的抑菌作用,且鞣质类化合物呈现广谱抗菌特性,并具有抗耐药菌作用。
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| 关 键 词： | 石榴皮 鞣质 黄酮 抑菌作用 |
| 文章编号： | 1008-0805（2007）10-2335-02 |
| 收稿时间： | 2007-03-14 |
| 修稿时间： | 2007-05-14 |
An Experimental Study on the Antibacterial Activity of the Tannin and Flavonoid in Punica granatum L. |
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| YANG Lin,ZHOU Ben-hong.An Experimental Study on the Antibacterial Activity of the Tannin and Flavonoid in Punica granatum L.[J].Lishizhen Medicine and Materia Medica Research,2007,18(10):2335-2336. |
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| Authors: | YANG Lin ZHOU Ben-hong |
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| Institution: | 1. College of Nursing, Three Gorges University, Yichang, 443000, China; 2. Pharmaceutical College of Wuhan University, Wuhan, 430072, China |
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| Abstract: | Objective To discuss the antibacterial activity of the tannin and flavonoid in Punica granatum L..Methods The tannin and flavonoid from Punica granatum L.were prepared,and subject to bacteriostatic tests in vitro by test tube continuously in order to observe their minimal in hibitory concentration(MIC) to Staphylococcus aureus,Shigellaf,Salmonella,Escherichia coli,Pseudomonas aeruginosa and Candida albicans.Results The tannin had antimicrobial activity against the six kinds of bacteria in different degrees,but the flavonoid had little antibacteria effect on Pseudomonas aeruginosa and Candida dlbicans.Conclusion The tannin has broad spectrum of antimicrobial activity and has antimicrobial effect to drug resistance bacteria. |
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| Keywords: | Punica granatum L Tannin Flavonoid Antibacterial activity |
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