不同炮制的决明子保肝及润肠通便作用研究

目的观察生、炒决明子的药理作用,并比较两者的差异。方法采用四氯化碳致小鼠急性肝损伤,测定血清ALT、AST含量;测量伊文思蓝在正常和便秘小鼠小肠内的推进距离;观察便秘小鼠的粪便性状、排便潜伏期和排便数目。结果生、炒决明子均有显著的保肝作用,能降低血清ALT、AST水平,两者比较,炒决明子保肝作用强于生决明子;生、炒决明子均能增强正常和便秘小鼠的小肠推进作用,改善便秘小鼠的粪便性状,缩短便秘小鼠的排便潜伏期,增加排便数目,两者比较作用相当。结论生、炒决明子均有保肝和润肠通便作用。在保肝降酶方面,炒决明子强于生决明子;在润肠通便方面,生决明子和炒决明子作用相当。

Liver- protective and Bowel- lubricating and Defecation- promoting Effects of Crude and Processed Semen Cassiae

Objective To investigate the pharmacological actions related with therapeutic effect and indications of crude and processed semen cassiae,and to compare the differences between them.Methods Serum contents of ALT and AST were determined in acute liver injury mice induced by CCl4,the intestinal propulsion of Evans blue was measured in normal mice and in constipation mice,and stool properties,defecation latency and defecate amounts in constipation mice were also investigated.Results Both crude and processed semen cassiae showed obvious liver-protective effects,and decreased the contents of ALT and AST in serum,but processed semen cassiae was better than crude in protecting liver.Both of them increased the intestinal propulsion in normal and constipation mice,improved the stool properties,shortened the defecate latency and increased the defecate amounts in constipation mice.Conclusion Both crude and processed semen cassiae have the effects of protecting liver,lubricating bowel and promoting defecation.The processed is superior to the crude in liver protection and enzyme decrease,and they have similar effect in lubricating bowel and promoting defecation.