| 膜滤工艺对安神补脑液药效的影响 |
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| 引用本文： | 许招懂,吴清和,蒋莉娟,黄萍,黎志坚,翟小玲,徐娟.膜滤工艺对安神补脑液药效的影响[J].中药新药与临床药理,2011(5). |
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| 作者姓名： | 许招懂 吴清和 蒋莉娟 黄萍 黎志坚 翟小玲 徐娟 |
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| 作者单位： | 1. 广州星群(药业)股份有限公司,广州,510288
2. 广州中医药大学中药学院,广州,510006 |
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| 基金项目： | 粤港关键领域重点突破招标项目 |
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| 摘 要： | 目的 研究膜滤工艺对安神补脑液有效性的影响.方法用小鼠自主活动、戊巴比妥钠阈剂量所致小鼠睡眠时间实验、戊巴比妥钠阁下催眠剂量试验和药物致小鼠惊厥实验,观察安神补脑液的镇静催眠作用；选择小鼠记忆获得障碍模型、小鼠记忆巩固障碍模型和小鼠记忆再现障碍模型,观察安神补脑液对记忆功能的改善作用；用小鼠常压缺氧、小鼠断头缺氧及游泳实验观察安神补脑液的抗缺氧、抗疲劳作用.结果膜滤安神补脑液可减少小鼠自主活动次数,延长戊巴比妥钠所致小鼠的睡眠时间,增加戊巴比妥钠阈下催眠剂量小鼠睡眠个数；对小鼠记忆获得障碍和记忆再现障碍均有明显的改善作用；同时,能增加小鼠常压缺氧的存活时间,并延长小鼠断头后的呼吸时间和喘息次数.结论膜滤安神补脑液具有镇静催眠、改善记忆和抗缺氧作用.
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| 关 键 词： | 安神补脑液 膜滤工艺 镇静催眠 改善记忆 抗缺氧 |
Influence of Membrane Filtration on Efficacy of Anshen Bunao Solutions |
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| XU Zhaodong,WU Qinghe,JIANG Lijuan,HUANG Ping,LI Zhijian,ZHAI Xiaoling,XU Juan.Influence of Membrane Filtration on Efficacy of Anshen Bunao Solutions[J].Traditional Chinese Drug Research & Clinical Pharmacology,2011(5). |
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| Authors: | XU Zhaodong WU Qinghe JIANG Lijuan HUANG Ping LI Zhijian ZHAI Xiaoling XU Juan |
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| Institution: | XU Zhaodong1,WU Qinghe2,JIANG Lijuan1,HUANG Ping2,LI Zhijian1,ZHAI Xiaoling1,XU Juan1(1.Guangzhou Xingqun Pharmaceutical Co.,Ltd.,Guangzhou 510288 China,2.School of Chinese Herbal Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510006,China) |
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| Abstract: | Objective To study the influence of membrane filtration on the efficacy of Anshen Bunao Solutions.Methods Spontaneous activities of mice,sleeping time in mice induced by threshold dose of sodium pentobarbital,induced dormancy in mice at subliminal dose of sodium pentobarbital,and drug-induced anticonvulsion in mice were observed to evaluate the sedative and hypnotic effect of Anshen Bunao Solutions.Memory acquirement deficits in mice(scopolamine model),memory consolidation deficits in mice(sodium nitrite mo... |
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| Keywords: | Anshen Bunao Solutions Membrane filtration Sedative and hypnotic effect Improvement of memory Anti-hypoxia |
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