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| 清开灵颗粒对AD模型小鼠学习记忆能力的影响 | |
| 引用本文： | 王永丽,韩璇,问慧娟,李玉巧,周雅静,魏芳.清开灵颗粒对AD模型小鼠学习记忆能力的影响[J].中药新药与临床药理,2011,22(4). |
| 作者姓名： | 王永丽 韩璇 问慧娟 李玉巧 周雅静 魏芳 |
| 作者单位： | 1. 河北大学临床医学院/河北大学附属医院药剂科,河北保定,071000 2. 河北大学基础医学院,河北保定,071000 3. 河北大学公共卫生学院,河北保定,071000 |
| 基金项目： | 河北省科学技术研究与发展计划项目 |
| 摘 要： | 目的 研究清开灵颗粒对AD模型小鼠学习记忆的影响。方法 选用东莨菪碱造模的雄性KM小鼠，用Morris水迷宫测试行为学指标，采用黄嘌呤氧化酶比色法测定超氧化物歧化酶(SOD)活性、硫代巴比妥酸法测定脂质过氧化产物丙二醛( MDA)含量、三硝基苯比色法测定脑内胆碱酯酶(AchE)活性。结果 清开灵颗粒能明显缩短模型小鼠游泳时间及游泳路程；显著提高脑组织SOD活性，降低MDA含量；明显降低脑组织AchE活性。结论 清开灵颗粒能改善造模小鼠的学习记忆功能，其机制可能与提高SOD活性、降低脑组织脂质过氧化物的含量、抑制AchE活性有关。 |
| 关 键 词： | 清开灵颗粒 学习记忆 抗氧化 胆碱酯酶 小鼠 |
Effect of Qingkailing Granule on Learning and Memory in Scopolamine-induced Alzheimer's Disease Modle Mice |
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| WANG Yongli,HAN Xuan,WEN Huijuan,LI Yuqiao,ZHOU Yajing,WEI Fang.Effect of Qingkailing Granule on Learning and Memory in Scopolamine-induced Alzheimer's Disease Modle Mice[J].Traditional Chinese Drug Research & Clinical Pharmacology,2011,22(4). | |
| Authors: | WANG Yongli HAN Xuan WEN Huijuan LI Yuqiao ZHOU Yajing WEI Fang |
| Institution: | WANG Yongli 1,HAN Xuan 2,WEN Huijuan 2,LI Yuqiao 2,ZHOU Yajing 2,WEI Fang 3 (1.Department of Pharmacy,Affiliated Hospital of Hebei University,Baoding 071000 Hebei,China,2.School of Basic Medicine,Hebei Uni-versity,3.School of Public Health,Hebei University,China) |
| Abstract: | Objective To study the effect of Qingkailing granule on learning and memory ability in Alzheimer's dis-ease model mice.Methods Male KM mice were used for the experiment,and Alzheimer's disease model was in-duced by scopolamine.Morris water maze was used to observe the learning and memory ability of model mice.Xan-thine oxidase colorimetry was used for the examination of superoxide dismutase(SOD)activity,thiobarbituric acid colorimetry for malondialdehyde content,and trinitrobenzene colorimetry for acetylcho... |
| Keywords: | Qingkailing granule Learning and memory Antioxidation Acetylcholinesterase Mice |
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