| 整合化学物质组学的整体系统生物学——中药复方配伍和作用机理研究的整体方法论 |
| |
| 引用本文： | 罗国安,梁琼麟,刘清飞,张荣利,杨辉华,李雪,王义明,贾伟,张卫东,张川,李贻奎.整合化学物质组学的整体系统生物学——中药复方配伍和作用机理研究的整体方法论[J].世界科学技术,2007,9(1):10-15,24. |
| |
| 作者姓名： | 罗国安 梁琼麟 刘清飞 张荣利 杨辉华 李雪 王义明 贾伟 张卫东 张川 李贻奎 |
| |
| 作者单位： | 清华大学化学系生命有机磷与化学生物学教育部重点实验室清华大学生命科学与医学研究院中药现代化研究中心 北京100084(罗国安，梁琼麟，刘清飞，张荣利，杨辉华，李雪，王义明)，上海交通大学药学院 上海200030(贾伟)，中国人民解放军第二军医大学药学院 上海200433(张卫东，张川)，中国中医科学院西苑医院 北京100091(李贻奎) |
| |
| 基金项目： | 科学技术部支撑项目;国家重点基础研究发展计划(973计划);国家科技攻关计划 |
| |
| 摘 要： | 本文以中医药学和系统生物学为基础,探讨建立一个整合化学物质组学的整体系统生物学体系,用于研究外部干预系统(中药复方)与生物应答系统(人体复杂系统)之间“系统-系统”的相互作用。整合化学物质组学的整体系统生物学提供了一个中医药学与现代科学交流融合的平台,有助于全面、系统、深刻的揭示中医方剂的药效物质基础和作用机理,阐明中药复方的配伍规律,指导复方新药研发,更好地传承和发展中医药理论。
|
| 关 键 词： | 整合化学物质组学的整体系统生物学 化学物质组学 中药复方 "系统-系统"相互作用 |
| 收稿时间： | 2006-12-08 |
| 修稿时间： | 2006-12-082006-12-14 |
Chemomics - integrated Global Systems Biology: A Holistic Methodology of Study on Compatibility and Mechanism of Formulas in Traditional Chinese Medicine |
| |
| Luo Guoan,Liang Qionglin,Liu Qingfei,Zhang Rongli,Yang Huihua,Li Xue,Wang Yiming,Jia Wei,Zhang Weidong,Zhang Chuan,Li Yikui.Chemomics - integrated Global Systems Biology: A Holistic Methodology of Study on Compatibility and Mechanism of Formulas in Traditional Chinese Medicine[J].World Science and Technology(Modernization of Traditional Chinese Medicine),2007,9(1):10-15,24. |
| |
| Authors: | Luo Guoan Liang Qionglin Liu Qingfei Zhang Rongli Yang Huihua Li Xue Wang Yiming Jia Wei Zhang Weidong Zhang Chuan Li Yikui |
| |
| Institution: | Key Lab of Chemical Biology of Ministry of Education, Department of Chemistry, Tsinghua University; Modern Research Center of TCM, Institute of biomedicine, Tsinghua University, Beijing 100084 ; School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240 ; College of Pharmacy, Second Military Medical University, Shanghai 200433 ; Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing 100091 |
| |
| Abstract: | A holistic methodology, chemomics-integrated global systems biology, was developed for the study of interaction between external intervention system (TCM) and biological response system (living system) on the basis of fundamental principle of Traditional Chinese Medicine (TCM) and systems biology. The methodology provided a platform of communication between TCM and modern science, unveiling the substantial foundation and pharmacological mechanism, understanding the theory of compatibility, guiding the development of new composite medicine, facilitating the succession and progress of theories of TCM. |
| |
| Keywords: | chemomics-integrated global systems biology chemomics Traditional Chinese Medicine formula system-system interaction |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
