益气活血利水法配合常规西医治疗原发性肾病综合征的临床研究

目的观察中西医结合疗法治疗原发性肾病综合征（PNS）的临床疗效。方法将248例PNS患者随机分为2组。对照组124例予常规西医治疗,治疗组124例在对照组治疗基础上加用黄芪当归合剂合当归芍药散加减,每日1剂,水煎分2次服。2组均1个月为1个疗程,6个疗程后观察临床疗效,24h尿蛋白定量、血清白蛋白、血脂、肾功能及尿纤维蛋白降解产物（FDP）,副作用和并发症及复发情况。结果治疗组治疗后24h尿蛋白定量、血清白蛋白、胆固醇、肌酐及尿FDP与本组治疗前比较差异均有统计学意义（P〈0.05,P〈0.01） 治疗组副作用和并发症发生率（19.4%）低于对照组（61.3%）（P〈0.01） 治疗组复发率4.0%,完全缓解率64.5%,对照组复发率11.3%,完全缓解率23.4%,2组比较差异均有统计学意义（P〈0.01）。结论益气活血利水法配合常规西医治疗原发性肾病综合征疗效确切。

Clinical research of combination of traditional Chinese medicine and western medicine on the treatment of primary nephrotic syndrome

Objective To investigate the clinical effect of combination of traditional Chinese medicine and western medicine on the treatment of primary nephrotic syndrome （PNS）. Methods 248 patients with PNS were di- vided randomly into two groups. The patients in treatment group （ n = 124） were treated by combination of traditional Chinese medicine and western medicine. Patients in control group （ n = 124） were treated by routine western medi- cine. The course was a month in both groups. The effect was evaluated by observing changes of 24h quantitative of urinary protein, plasma albumin, blood -fat, renal function, FDP and recurrence in two groups before and after treat- ment. Results There were obvious abnormality in biochemical indicators and FDP before treatment in two groups （ P 〈 0. 01 or 〈 O. 05）. The total effective rate in treatment group （96.0 % ） was higher than that in control group （75.8 %, P 〈0.05 ）. The incidence rate of side- effects and complication in control group （61.3%） was higher than that in treatment group （19.4%）. The recurrent rate in treatment group was lower （4.0%） than that in control group （ 11.3% ）. Conclusion Combination of traditional Chinese medicine and western medicine was effective on the treatment of primary nephrotic syndrome.