湿阻热郁型与阴虚燥热型原发性干燥综合征相关因素对比研究

目的对比原发性干燥综合征(PSS)湿阻热郁型与阴虚燥热型在生活习惯、唾液腺分泌及脏器累及等方面的差异。方法收集35例湿阻热郁型PSS患者和82例阴虚燥热型患者,分别比较2型患者吸烟饮酒、嗜食肥甘厚味及肥胖情况;龋齿数量、含片溶解时间;14C呼气试验检测幽门螺杆菌(Hp)阳性率、胸部CT检测间质性肺病发病率;进行血尿酸、血肌酐及血、尿、唾液β2微球蛋白(β2-MG)检测。结果 2型均无吸烟酗酒史。2型嗜食肥甘厚味情况及肥胖情况比较差异有统计学意义(P<0.05),湿阻热郁型嗜食肥甘厚味情况较阴虚燥热型严重,肥胖人数高于阴虚燥热型。湿阻热郁型龋齿数量及含片溶解时间均多于阴虚燥热型(P<0.05,P<0.01),Hp阳性率及间质性肺病发病率高于阴虚燥热型(P<0.05)。2型血尿酸、血肌酐及尿β2-MG比较差异无统计学意义(P>0.05),湿阻热郁型血β2-MG及唾液β2-MG水平高于阴虚燥热型(P<0.05)。结论湿阻热郁型PSS与阴虚燥热型在体质量、饮食情况、龋齿数量、累及脏器及β2-MG等方面存在差异。对这些项目的分析有助于对PSS中医辨证分型临床特点的认识,从而为中医辨证客观化提供循证基础。

Comparative study of relevant factors of dampness-heat stagnation type and yin defldency with dryness heat type primary Sjogren syndrome

Objective To elucidate the difference between dampness-heat stagnation type and yin deficiency with dryness heat type primary Sjogren syndrome in such factors as life habits,salivary glands secretion,organ involvement,β2-MG.Methods A questionaire to investigate the habit for drinking and smoking,eating heavy taste food was conducted in thirty-five dampness-heat stagnation type Sjogren syndrome（DHS-PSS） and eighty-two yin deficiency with dryness heat type Sjogren syndrome（YDDH-PSS）.The number of dental caries,oral sugar clearance time,14C breath test for detection of Hp infection rate,chest CT detection of interstitial lung disease incidence;serum uric acid,creatinine,and blood,urine,saliva,β2-microglobulin（β2-MG） detection of all the patients was elevated.Results There was no significant difference in age,duration of disease,gender ratio,the habit for smoking and drinking between the two types of primary Sjogren syndrome.Compared with the YDDH-PSS group,the DHS-SS group had more serious bad food habit in eating greasy,sweet and heavy-taste food,higher BMI,higher frequency interstitial pneumonia.Time of oral Sugar clearance in DHS-PSS group was significantly longer than that in YDDH-PSS group.The serum and salivary β2-MG were significantly higher in DHS-PSS group than that in YDDH-PSS group.Conclusion There are differences between dampness-heat stagnation type and yin deficiency with dryness heat type primary Sjogren syndrome in the duration of disease,BMI,diet,the number of dental caries,involved organs and β2-MG in,etc.The analysis of these projects contribute to the understanding of the PSS traditional Chinese medicine syndrome differentiation clinical features,and provide the evidence base for the objective of the traditional Chinese medicine syndrome differentiation.