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| 中药半枝莲提取物体外抗肿瘤活性研究 | |
| 引用本文： | 王刚,董玫,郭会灿,赵松.中药半枝莲提取物体外抗肿瘤活性研究[J].河北中医,2006,28(9):701-702. |
| 作者姓名： | 王刚 董玫 郭会灿 赵松 |
| 作者单位： | 1. 河北化工医药职业技术学院制药工程系,石家庄,050031 2. 河北医科大学基础医学院法医系,石家庄,050017 3. 石家庄职业技术学院化工制药系,石家庄,050081 4. 河北医科大学基础医学院病理教研室,石家庄,050017 |
| 摘 要： | 目的探讨中药半枝莲提取物的体外抗肿瘤作用。方法分别选用人红白血病细胞株K562,人胃癌细胞株BGC823,人食管癌细胞株TE13,用MTT法测定半枝莲醇提物(SBE)和水提物(SBW)对体外肿瘤细胞的抑制作用。结果体外抑瘤实验表明,对SBE敏感的最低药物浓度分别为7.8、15.6和15.6μg/ml,半数抑制率(IC50)分别为25.7、30.8和30.8μg/ml,对SBW敏感的最低药物浓度分别为15.6、15.6和15.6μg/ml。IC50分别为27.6、146.3和57.4μg/ml。结论SBE和SBW体外均有很强的抗肿瘤作用,且SBE的作用高于SBW。 |
| 关 键 词： | 半枝莲 抗肿瘤 药理学 |
| 文章编号： | 1002-2619（2006）09-701-02 |
| 收稿时间： | 2006-03-10 |
| 修稿时间： | 2006-03-10 |
Experimental research on Herba Scutellariae Darbatae extract of its antineoplastic activity in vitro |
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| WANG Gang, DONG Mei, GUO Huican,et al..Experimental research on Herba Scutellariae Darbatae extract of its antineoplastic activity in vitro[J].Hebei Journal of Traditional Chinese Medicine,2006,28(9):701-702. | |
| Authors: | WANG Gang DONG Mei GUO Huican |
| Institution: | Deparment of Pharmacy Engineering, Chemical Pharmaceutical Vocational Technology College, Hebei, Shijiazhuang 050031 |
| Abstract: | Objective To research antineoplastic activity of Herba Scutellariae Darbatae extractive in vitro.Methods Herba Scutellariae Darbatae extractive on tumor cell proliferation and influence of the spleen cell proliferation active in mice were observed with MTT method.Results Herba Scutellariae Darbatae extractive had a strong inhibition effect to variety of tissue origin tumor cell and a promotion effect on the spleen cell of the mice.Conclusion Herba Scutellariae Darbatae aqueous and ethanol extracts have strong anti-tumor effect in vitro,and ethanol extract has better effect than aqueous extract.Herba Scutellariae Darbatae as a kind of anti-tumor drug needs further researched and developed. |
| Keywords: | Herba Scutellariae Darbatae Anti-tumor effects |
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