Pharmacokinetic comparisons of hydroxysafflower yellow A in normal and blood stasis syndrome rats |
| |
Authors: | Yun Tian Zhi-Fu Yang Yan Li Yi Qiao Jing Yang Yan-Yan Jia Ai-Dong Wen |
| |
Institution: | 1. Department of Pharmacy, Xijing Hospital, The Fourth Military Medical University, No. 127, Changle West Road, Xi’an, China;2. Department of Comprehensive Diagnosis and Therapy, Xijing Hospital, The Fourth Military Medical University, No. 127, Changle West Road, Xi’an, China |
| |
Abstract: | Ethnopharmacological relevanceSafflower is a popular Traditional Chinese Medicine (TCM) to invigorate the blood and dispel ‘blood stasis’, which arises from poor blood circulation. The differences of pharmacokinetic properties between normal and blood stasis syndrome rats were seldom reported.Aim of the studyThe present study was conducted to evaluate the pharmacokinetics of hydroxysafflower yellow A (HSYA) following oral administration of hydroxysafflower yellow A and safflower extract with approximately the same dose of HSYA 100 mg/kg in both normal and acute blood stasis rats.Materials and methodsThe animals were orally administered with HYSA monomer and safflower extract. The blood samples were collected according to the time schedule. The concentrations of HSYA in rat plasma were determined by HPLC. Various pharmacokinetic parameters were estimated from the plasma concentration versus time data using non-compartmental methods.ResultsIt was found that AUC0–t, Cmax, Vd and CL of HSYA in both HSYA monomer and safflower extract in acute blood stasis rats were with significant difference (P < 0.05) comparing with that in normal rats.ConclusionsThe results indicated that HSYA was with high uptake and eliminated slowly in the animals with blood stasis syndrome, suggesting that the rate and extent of drug metabolism was altered in acute blood stasis animals. |
| |
Keywords: | Hydroxysafflower yellow A Safflower extract Pharmacokinetics Blood stasis syndrome |
本文献已被 ScienceDirect 等数据库收录! |
|