首页 | 本学科首页   官方微博 | 高级检索  
检索        


Evidence of anti-inflammatory effects of Passiflora edulis in an inflammation model
Authors:Montanher Ana Beatriz  Zucolotto Silvana Maria  Schenkel Eloir Paulo  Fröde Tânia Silvia
Institution:Department of Clinical Analysis, Center of Health Sciences, Federal University of Santa Catarina, Campus Universitário, Trindade, 88040-970 Florianópolis, SC, Brazil.
Abstract:The popular medicine Passiflora edulis has been used as a sedative, tranquilizer, against cutaneous inflammatory diseases and intermittent fever. Most of the pharmacological investigations of Passiflora edulis have been addressed to its Central Nervous System activities, such as anxiolytic, anticonvulsant and sedative actions. Otherwise, there are few reports about the anti-inflammatory activity of the Passiflora species. The aim of this study was to investigate the mechanism of the anti-inflammatory effect of aqueous lyophilized extract obtained from leaves of Passiflora edulis var. flavicarpa Degener (Passifloraceae) in the mouse model of pleurisy induced by carrageenan (Cg), bradykinin, histamine or substance P, observing the effects upon leucocytes migration, myeloperoxidase (MPO), nitric oxide (NO) concentrations and tumor necrosis factor-alpha (TNFalpha) and interleukin-1 beta (IL-1beta) levels. RESULTS: Passiflora edulis (250mg/kg) administered by intraperitoneal route (i.p.) inhibited the leukocyte, neutrophils, myeloperoxidase, nitric oxide, TNFalpha and IL-1beta levels (P<0.01) in the pleurisy induced by carrageenan. Passiflora edulis (250-500mg/kg, i.p.) also inhibited total and differential leukocytes in the pleurisy induced by bradykinin, histamine or substance P (P<0.05). CONCLUSION: Several mechanisms, including the inhibition of pro-inflammatory cytokines (TNFalpha, IL-1beta), enzyme (myeloperoxidase) and mediators (bradykinin, histamine, substance P, nitric oxide) release and/or action, appear to account for Passiflora edulis's actions.
Keywords:Cav  cavity  Cg  carrageenan  CV  coefficient of variation  Dexa  dexamethasone  ELISA  enzyme-linked immunosorbent assay  E-selectin  endothelial selectin type E  ICAM-1  intercellular adhesion molecule type 1  IL-1β  interleukin-1 beta  i  p    intraperitoneal  i  pl    intrapleural  MPO  myeloperoxidase  NF-κB  nuclear factor kappa B  NO  nitric oxide  NO2?  nitrite  NO3?  nitrate  PBS  phosphate buffered saline  P  edulis  Passiflora edulis var  flavicarpa Degener  Sal  saline  TNFα  tumor necrosis factor-alpha  var  variation
本文献已被 ScienceDirect PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号