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Anti-inflammatory activity of Sedum kamtschaticum |
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| Authors: | Kim Dong Wook Son Kun Ho Chang Hyeun Wook Bae KiHwan Kang Sam Sik Kim Hyun Pyo |
| Institution: | a College of Pharmacy, Kangwon National University, Chunchon 200-701, South Korea b Department of Food & Nutrition, Andong National University, Andong 760-749, South Korea c College of Pharmacy, Yeungnam University, Gyongsan 712-749, South Korea d College of Pharmacy, Chungnam National University, Chungnam, South Korea e Natural Products Institute, Seoul National University, Seoul 110-460, South Korea |
| Abstract: | Sedum kamtschaticum Fischer (Crassulaceae) has been used as a folk medicine in North-East Asia for treating inflammatory disorders. The present investigation was carried out to establish in vivo anti-inflammatory activity and cyclooxygenase-2 modulating activity of this plant material. The methanol extract of Sedum kamtschaticum significantly inhibited mouse croton oil-induced ear edema (24–47% inhibition at 50–400 mg/kg) and rat paw edema (24–30% inhibition at 400–800 mg/kg) by oral administration. Prednisolone (10 mg/kg) showed 54 and 36% inhibition in the same animal models, respectively. Sedum kamtschaticum also showed significant inhibitory activity against mouse ear edema induced by multiple treatment of phorbol ester for 3 days. In addition, Sedum kamtschaticum exhibited potent analgesic activity against mouse acetic acid-induced writhing (IC50=125 mg/kg), while aspirin (200 mg/kg) showed 57% inhibition. Using lipopolysaccharide-treated RAW 264.7 cells, down-regulation of cyclooxygense-2 expression was found to be one of the cellular action mechanisms of anti-inflammation by Sedum kamtschaticum. |
| Keywords: | Sedum kamtschaticum Fischer Anti-inflammation Analgesic activity Cyclooxygenase |
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