Relaxant effects of the essential oil of Ocimum gratissimum on isolated ileum of the guinea pig |
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| Authors: | Madeira Socorro V F Matos Francisco José A Leal-Cardoso José H Criddle David N |
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| Institution: | 1. Institute for Aerospace Studies, University of Toronto, Toronto, Canada;2. Luleå University of Technology, Kiruna, Sweden |
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| Abstract: | The effects of the essential oil of Ocimum gratissimum L. (Labiatae) (EOOG) on guinea pig ileum were studied. EOOG (0.1-1000 microg/ml) reversibly and concentration-dependently relaxed the basal tone of the ileum and reversed the tonic contractions induced by 60 mM KCl and 10 microM acetylcholine, with IC(50) values of 23.8+/-5.2, 18.6+/-4.0 and 70.0+/-4.6 microg/ml, respectively. Our results show that EOOG exerts relaxant effects on intestinal smooth muscle, consistent with the popular use of the plant to treat gastrointestinal disorders. |
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