Anti-inflammatory and analgesic activity of Biebersteinia multifida DC. root extract |
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Authors: | Farsam H Amanlou M Reza Dehpour A Jahaniani F |
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Affiliation: | Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, 14155-6451, Tehran, Iran. farsam@sina.tums.ac.ir |
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Abstract: | The root of Biebersteinia multifida DC (Geraniaceae), a native plant of Iran, has been used topically for the treatment of musculoskeletal disorders as a folk medicine. The anti-inflammatory and analgesic effects of the root extract were studied using carrageenan induced edema and formalin tests. A similar activity was seen between Biebersteinia multifida root extract (10 mg/kg; i.p.) and indomethacin (4 mg/kg; i.p.) in carrageenan test. The results of formalin test showed the analgesic activity of the root extract (50 mg/kg; i.p.) was comparable with morphine (10 mg/kg; i.p.) at the first phase of formalin test. Furthermore, the probable ulcerogenic activity of the root extract was also studied. The extract did not show any ulcerogenic effect at anti-inflammatory doses (10 mg/kg; p.o.). |
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