Pharmacological basis for the gut stimulatory activity of Raphanus sativus leaves |
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Authors: | Gilani Anwarul Hassan Ghayur M Nabeel |
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Institution: | Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan. anwar.gilani@aku.edu |
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Abstract: | The crude extract of Raphanus sativus leaves (Rl.Cr) showed a dose-dependent (0.03-5.0 mg/ml) spasmogenicity in guinea-pig ileum and colon. The effect was insensitive to atropine pre-treatment but was completely abolished by pyrilamine indicating involvement of histaminergic (H(1)) receptors. The contractile effect at high doses (3.0-5.0mg/ml) was followed by relaxation. Rl.Cr also enhanced the transit of charcoal meal in mice at 30-100 mg/kg. The petroleum spirit, chloroform and aqueous fractions all showed histaminergic activity in ileum; aqueous fraction being more potent. The study shows the presence of a histaminergic component(s) along with a weak spasmolytic factor thus providing sound mechanistic basis for the traditional use of the plant in constipation. |
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