Comparative pharmacokinetic study of paeoniflorin after oral administration of decoction of Radix Paeoniae Rubra and Radix Paeoniae Alba in rats |
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Authors: | Wang Chang-Hong Wang Rui Cheng Xue-Mei He Yu-Qi Wang Zheng-Tao Wu Cheng Cao Jing |
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Affiliation: | aThe Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, China bKey Laboratory of Standardization of Chinese Medicines, Ministry of Education, 1200 Cailun Road, Shanghai, China cShanghai R&D Centre for Standardization of Chinese Medicines, 1200 Cailun Road, Shanghai, China |
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Abstract: | An investigation was designed and conducted to compare the pharmacokinetics difference of paeoniflorin after oral administration of the extracts of Radix Paeoniae Rubra and Radix Paeoniae Alba to rats on separate occasions. Quantification of paeoniflorin in rat plasma was achieved using a simple and rapid HPLC method for pharmacokinetic study. After oral administration of decoctions of Radix Paeoniae Rubra and Radix Paeoniae Alba, paeoniflorin was absorbed and reached a maximum concentration of 3.69 ± 1.46 and 1.46 ± 0.29 (p < 0.05) μg/ml at 1.67 ± 0.43 and 0.80 ± 0.35 h (p < 0.05), respectively. Compared to the AUC (18.85 ± 7.54 μg h/ml) after oral administration of the paeoniflorin solution, a smaller AUC (10.61 ± 1.51 μg h/ml, p < 0.05) and a larger AUC (24.89 ± 7.41 μg h/ml) of paeoniflorin after oral administration of the decoctions of Radix Paeoniae Alba and Radix Paeoniae Rubra were obtained, respectively. There were statistically significant differences in pharmacokinetic parameters of paeoniflorin including the tmax, Cmax, AUC, t1/2, CL, and Vd among the animals orally administered the decoctions of Radix Paeoniae Rubra and Radix Paeoniae Alba. In particular, the parameters of tmax, Cmax, and AUC of paeoniflorin were remarkably increased (P < 0.05, P < 0.001) when oral administering paeoniflorin in the decoctions of Radix Paeoniae Rubra, but t1/2, Vd, and CL were decreased (P < 0.05 or P < 0.01), in comparison of the decoction of Radix Paeoniae Alba. |
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Keywords: | Paeoniflorin Pharmacokinetic Radix Paeoniae Rubra Radix Paeoniae Alba |
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