三黄三仙汤抗疲劳作用的实验研究

目的：研究三黄三仙汤对小鼠的抗疲劳作用。方法：实验设三黄三仙汤高、中、低3个剂量（5.12、2.56、1.28g/mL分别相当于人推荐量的16、8、4倍）,另设阴性对照组（蒸馏水）,连续给药30d。结果：与阴性对照组（蒸馏水）相比,高、中剂量组能明显延长小鼠负重游泳时间,差异均有显著性（P〈0.05）;高、中剂量组能明显降低小鼠运动后血清尿素含量,差异均有显著性（P〈0.05）;高、中剂量组能明显提高小鼠运动时肝糖原含量,差异均有显著性（P〈0.05）;高、中剂量组能明显降低小鼠游泳后血乳酸含量,三剂量组均能明显降低小鼠运动后血乳酸曲线下面积含量,差异均有显著性（P〈0.05）。结论：三黄三仙汤具有提高小鼠抗疲劳的作用。

The Experimental Research On Anti- fatigue Effect of Sanhuang Sanxian Decoction

Objective ：To explore the effection of Sanhuang Sanxian Decoction on mice anti -fatigue. Methods ：Mice were randomly divided into four groups：low,middle and high dose of Sanhuang Sanxian Decoction groups （5.12,2.56, 1.28 g/mL）, and control group. Swimming time, the contents of blood urea nitrogen, blood lactic acid and liver glycogen of mice had been observed. Conclusions High and middle dose groups could significantly prolong swimming time in mice, de- crease the contents of blood urea nitrogen and blood lactic acid, increase liver glycogen after strenuous exercise. All doses of Sanhuang Sanxian Decoction could decrease the area below blood lactic acid curve. Conclusion：The study showed that Sanhuang Sanxian Decoction had anti -fatigue effects.