自拟疏肝养血汤对乳腺癌患者肿瘤组织血管内皮生长因子受体的影响

目的：研究自拟疏肝养血汤对乳腺癌患者肿瘤组织血管内皮生长因子（VEGF）及其受体的影响,进一步探讨其作用机制,为临床应用提供可靠的依据。方法：选取2010年1月—2012年12月接收的52例女性乳腺癌患者为研究对象,采用随机数字法均分为两组。对照组患者给予新辅助化疗;观察组患者在对照组的基础上给予自拟疏肝养血汤口服治疗,100 mL/次,2次/d。比较两组患者治疗前后LVD、MVD、VEGF-A及其受体flk-1、VEGF-C及其受体flt-4;统计分析两组临床疗效和不良反应发生率。结果两组患者治疗前LVD、MVD差异无统计学意义（P〉0.05）;治疗后,观察组LVD、MVD水平显著低于对照组（P〈0.05）。两组患者治疗前VEGFA、VEGF-C、flk-l、flt-4阳性率比较差异均无统计学意义（P〉0.05）;治疗后,观察组VEGF-A、VEGF-C、flk-l、flt-4阳性率均显著低于对照组（P〈0.05）。观察组总有效率明显高于对照组（77.0%VS 46.1%,χ2=5.200,P〈0.05）;两组患者不良反应发生率比较,差异没有统计学意义（23.1%VS 19.2%,χ2=0.495,P〉0.05）。结论：自拟疏肝养血汤在减少乳腺癌患者的LVD、MVD水平,降低VEGF-A及其受体flk-l、VEGF-C及其受体flt-4阳性率方面有正向作用,可提高乳腺癌的临床治疗效果。

The Effect of Shuganyangxue Decoction on VEGF and Its Receptor in Tumor Tissue of Patients with Breast Cancer

Objective： To study the effect of self- made Shuganyangxue decoction on vascular endothelial growth factor（VEGF） and its receptors in tumor tissue of patients with breast cancer,so as to explore its action mechanism and provide reliable basis for its clinical application. Methods：52 cases of patients with breast cancer were divided into two groups randomly： Patients in Control group were given neoadjuvant chemotherapy; while patients in Observation group were given Shuganyangxue decoction on base of Control group. The indicators including LVD,MVD,VEGF- A and flk- 1,VEGF- C and flt- 4 were compared between groups; the clinical effect and adverse effects rate were compared too. Results：Before treatment,the difference of LVD and MVD of two groups had no statistical significance（ P〈0. 05）. After treatment,the lever of LVD and MVD of patients in Observation group was significantly lower than those in Control group（P〈0. 05）.Before treatment,there was no significant difference in the positive rate of VEGF- A,flk- 1,VEGF- C,flt- 4 between groups（P〈0. 05）. After treatment,the positive rate of VEGF- A,flk- 1,VEGF- C,flt- 4 of patients in Observation group were significantly lower than those in Control group（P〈0. 05）. Further more,the total effective rate of patients in Observation group was significant higher than that in Control group（77. 0% VS 46. 1%,χ2= 5. 200,P〈0. 05）; while the adverse effects rate of two groups had no statistical significance（23. 1% VS19. 2%,χ2= 0. 495,P〈0. 05）. Conclusion：The self- made Shuganyangxue decoction has positive effect on reducing the lever of LVD and MVD and decreasing the expression of VEGF- A,flk- 1,VEGF- C and flt- 4,which is benefit to its therapy.