红花黄色素前列地尔和甲钴胺联合治疗糖尿病周围神经病变的疗效观察

目的：观察红花黄色素、前列地尔和甲钴胺联合治疗糖尿病周围神经病变的疗效。方法：将60例2型糖尿病合并周围神经病变患者随机分为2组,对照组30例,治疗组30例。治疗组用注射用红花黄色素150mg加入生理盐水250mL中静脉滴注,1日1次,前列地尔注射液20μg加入生理盐水100mL中静脉滴注,1日1次,甲钴胺注射液0.5mg肌肉注射,1日1次,对照组单纯用甲钴胺0.5mg肌肉注射,1日1次,两组疗程均为14天。观察两组临床疗效及其神经传导速度的改变。结果：治疗组临床疗效总有效率为80.0%,对照组总有效率为53.3%,两组差别有统计学意义,治疗组优于对照组（P〈0.05）。两组治疗后神经传导速度比治疗前均有显著提高,治疗组优于对照组（P〈0.05）。结论：红花黄色素、前列地尔和甲钴胺联合是治疗糖尿病周围神经病变的有效方法。

Safflower Yellow Pigment Alprostadil Combined with Methylcobalamin for Treating Diabetic Peripheral Neuropathy

Objective：We observe the efficacy of safflower yellow pigment,alprostadil,combined with methylcobalamin in treatment of diabetic peripheral neuropathy.Methods： 60 patients with type 2 diabetes suffered from peripheral neuropathy were randomly divided into two groups.30 cases were for the treatment group,control group 30 cases.The treatment group were injected with safflower yellow pigment 150mg in 250mL normal saline intravenous infusion per day,20μg alprostadil injection by adding 100mL of normal saline intravenous infusion once daily,methylcobalamin injection 0.5mg per day.The control group simply using methylcobalamin intramuscular injection 0.5mg daily.Clinical efficacy and nerve conduction velocity changes were evaluated after the course of treatment lasting 14d.Results：The total effective rate of clinical efficacy was much higher in treatment group than which in control group（P〈0.05）,80.0% and 53.3% for treatment group and control group respectively.The nerve conduction velocity were increased significantly after treatment for both groups,and improved more significantly for the treatment group（P〈0.05）.Conclusion：Safflower yellow pigment,alprostadil,combined with methylcobalamin were effective for treating diabetic peripheral neuropathy.