通心络对高脂血症兔血清脂质过氧化的影响

目的：观察通心络对高脂血症兔血清脂质过氧化的影响。方法：32只新西兰大白兔随机分成4组,分别予以正常饮食（A组）、通心络＋高胆固醇饮食（B组）、维生素E＋高胆固醇饮食（C组）、高胆固醇饮食（D组）。喂养30d后取血清测总胆固醇（TC）、超氧化物歧化酶（SOD）活力和丙二醛（MDA）含量。结果：TC含量：A组明显低于其他各组（P〈0.01）,C组明显低于B、D两组（P〈0.01）,B.D两组比较P〉0.05;SOD活力：A组与B,C,D组比较P〈0.01,B、C组明显高于D组（P〈0.05）,B,C组比较P〉0.05;MDA含量：A组与B,C,D组比较P〈0.01,B,C组与D组P〈0.05,B,C组比较P〉0.05。结论：通心络可以减少各种氧自由基的产生,降低脂质过氧化的水平。

Effect of Tongxinluo on Lipid Peroxidation in Hypercholester of Rabbits

Objective：To observe the Effect of Tongxinluo on lipid peroxidation in hyperch0lester 0f rabbits. Method：This paper is to observe the effect of Tongxinluo on lipid peroxidation in hypercholesterol rabbits. A total of 32 rabbits were randomly divided into 4 groups：normal Diet（group A ）,Tongxinluo plus hypercho1estero1 diet（groupB）,VitE plus hypercholesterol diet（group C）and hypercholesterol diet（group D）.After 30d,serum total cholesterol（TC）,superoxide dismutase （SOD）and malondialdehyde （M DA）were determined.Result：The amount of TC in group A was much lower than that in other groups（P〈0.01）;TC in group C was greatly lower than that in group B and D（P〈0.01）.There was no difference between B and D group （P〉0.05）.For the activity of SOD,A group was higher than B,C and D group （P〈0.01）; The activity of SOD in group B was higher than that in group D（P〈0.05）; There was no difference between B and C group （P〉0.05）.For the amount of MDA,A group was obviously lower than B,C and D group （P〈0.01）; The amount of MDA in B and C group was lower than that in group D（P〈0.05）; There was no difference between B and C group （P〉0.05）. Conclusion ：Tongxinluo can reduce all kinds of oxygen free radicals and decline the level of lipid peroxidation.