血塞通注射液治疗急性脑梗死30例临床观察

目的：观察血塞通注射液治疗急性脑梗死的临床疗效及安全性。方法：60例急性脑梗死患者随机分为两组各30例。两组均给予拜阿司匹林。治疗组采用血塞通注射液静滴，对照组加用冠心宁注射液。疗程均为14天。结果：治疗组基本痊愈22例，显著进步3例，进步2例，无变化2例，恶化1例，总有效率为90．0％（95％CI=73．45％-97．90％）；对照组基本痊愈12例，显著进步6例，进步3例，无变化7例，恶化2例，总有效率为70．0％（95％CI=50．55％～85．25％）；两组综合疗效比较（n=2．3264，P=0．0200），差异有显著性意义；治疗组改善神经功能缺损评分及生活能力评分优于对照组（P〈0．01）；对血液流变学的作用亦优于对照组。结论：血塞通注射液治疗急性脑梗死疗效优于冠心宁注射液，其结局事件的收益为oR=0．26（95％CI=0．06-1．08），NNT=5（95％CI=4．53—5．58）。

Clinical Observation of Panax Notoginoside Injection on Aute Cerebral Infarction,A Report of 30 Cases

Objective： To observe the clinical effect and safety of Panax Notoginoside Injection （PNS） on a- cute cerebral infarctions. Method： 60 cases with acute cerebral infarction were divided into two groups randomly. Besides bay-aspirin to all the cases in the two groups, 800mg of PNS Injection in 250 ml of 0. 9% sodium chloride injection was given to 30 cases in treatment group by IV infusion, once a clay for 14 days. And 30ml Perhexiline Injection in 250ml of 0. 9% sodium chloride injection was given to the ones in control group by IV inusion, also once a day for 14 days. Result： In treatment group 22 cases were recovered, 3 ones excellent, 2 ones effective, 2 ones unchanged and one deteriorated. The total effective rate was 90.0% （95% CI =73.45% -97.90% ）. In con- tro] group 12 cases were recovered, 6 ones excellent, 3 ones effective, 7 ones unchanged and 2 ones deteriorated. The total effective rate was 70.0% （95% CI = 50.55%-85.25%）. About comprehend curative effect, u = 2. 326 4, P = 0. 020 0, the difference was significant. Treatment group did better than control group on improving the scores of neurologic impairment and viability （P 〈 0.01 ） . So did on haemorheology. Conclusion ： Panax Notoginoside Injection has better effect than Perhexiline Injection on acute cerebral infarction, OR = 0. 26 （95% CI = 0. 06-1.08）, NNT =5 （95% CI =4. 53-5.58）